International Aldosterone Conference - Cardiovascular

国际醛固酮会议 - 心血管

基本信息

批准号：
8130434
负责人：
GORDON H WILLIAMS
金额：
$ 1.5万
依托单位：
INTERNATIONAL ALDOSTERONE CONFERENCE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-04-01 至 2012-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8130434
关键词：
Adrenal Cortex Adrenergic Agonists Aldosterone Angiotensin II Angiotensin-Converting Enzyme Inhibitors Animals Biochemistry Blood Vessels Cardiac Myocytes Cardiovascular Diseases Cardiovascular system Caveolins Cells Clinical Trials Conflict (Psychology)Corticotropin Data Development Diabetes Mellitus Discipline Disease Endocrinologist Endothelial Cells Endothelin Epithelial Cells Experimental Models Explosion Floods Fostering Functional disorder Genetic Growth Health Heart Diseases Homeostasis Human Hyperaldosteronism Hypertension Individual International Kidney Lysine Mediating Metabolic syndrome Mineralocorticoid Receptor Modeling Molecular Molecular and Cellular Biology Mononuclear Natriuretic Peptides Neurons Obesity Outcome Pathway interactions Pattern Physiology Potassium Receptor Activation Regulation Research Personnel Role Science Series Sleep Apnea Syndromes Smooth Muscle Myocytes Stroke System Therapeutic Human Experimentation Time cardiovascular injury cardiovascular risk factor career meetings prevent programs rapid growth receptor skills symposium vascular inflammation

项目摘要

DESCRIPTION (provided by applicant): We are requesting support for a series of annual conferences from 2011 - 2015 to be called the International Aldosterone Conference-Cardiovascular. The objective of these conferences is to expand the understanding of the science - from cells to humans - underlying the role of aldosterone and mineralocorticoid receptor activation in increasing cardiovascular risk across a broad range of cardiovascular diseases, e.g., hypertension, diabetes mellitus, obesity, sleep apnea, metabolic syndrome, heart disease, stroke and renal dysfunction. This objective will be accomplished by using the approach and format of the International Aldosterone Conference. This approach has been successful in the past to accomplish a similar objective directed at the mechanism of activation of the mineralocorticoid receptor in epithelial cells, e.g., in the kidney. The format consists of an annual meeting for five years. Each annual meeting will consist of three half-day sessions. Each session begins with a state-of-the-art speaker who is an expert in a specific discipline related to aldosterone but who is not per se and expert in aldosterone. The attendees are experts and researchers in aldosterone/mineralocorticoid receptor physiology, pathophysiology, clinical trials, biochemistry, molecular and cellular biology and genetics. Young investigators in the field are encouraged to attend. The outcome from this series of conferences will be better understanding of the factors underlying the adverse cardiovascular effects produced by an activated aldosterone/mineralocorticoid receptor system. With this increased understanding will come better approaches to prevent and/or treat cardiovascular diseases.

描述（由申请人提供）：我们要求为2011年至2015年的一系列年度会议提供支持，称为国际醛固酮会议 - 钟血管。这些会议的目的是扩展对科学的理解 - 从细胞到人 - 醛固酮和矿物皮质激活受体激活在多种心血管疾病中增加心血管风险增加的作用，例如高血压，高血压，糖尿病，糖尿病，糖尿病，肥胖，肥胖，睡眠apnea apnea，prenea，pren疾病，培养基，内定位疾病和心脏，心脏，心脏，疾病，疾病，疾病，疾病，疾病，疾病。该目标将通过使用国际醛固酮会议的方法和格式来实现。过去，这种方法已经成功地完成了一个针对上皮细胞中矿物皮质激素受体激活机制的类似物体，例如在肾脏中。该格式由五年的年度会议组成。每个年度会议将包括三个半天会议。每个会议始于一位最先进的演讲者，他是与醛固酮有关的特定学科专家，但不是本身本身和醛固酮专家。与会者是醛固酮/矿物皮质受体生理学，病理生理学，临床试验，生物化学，分子和细胞生物学和遗传学的专家和研究人员。鼓励该领域的年轻调查员参加。这一系列会议的结果将更好地理解激活的醛固酮/矿物皮质激活受体系统产生的不良心血管效应的因素。随着这种理解，将出现更好的方法来预防和/或治疗心血管疾病。