Swine in Biomedical Research Conference 2011 Creating the Building Blocks: Genomi

2011 年猪生物医学研究会议创建构建模块：Genomi

• 批准号: 8118678
• 负责人: LAWRENCE B SCHOOK
• 金额: $ 1万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8118678
• 关键词: Address; Animal Model; Animals; Area; Behavior; Biomedical Engineering; Biomedical Research; Cardiovascular Diseases; Categories; Clinical; Cognition Disorders; Communities; Development; Diagnosis; Discipline; Disease; Educational workshop; Family suidae; Funding; Genetic; Genomics; Health; Housing; Human; Immunology; Individual; Information Technology; Investigation; Joints; Knowledge; Lead; Life Style; Methodology; Modeling; Orthopedics; Pathway interactions; Physiology; Protocols documentation; Regenerative Medicine; Research; Research Personnel; Resources; Rodent Model; Science; Series; Targeted Research; Tissue Microarray; Transcend; Transgenic Organisms; Transplantation; United States National Institutes of Health; Work; human disease; next generation; novel strategies; nutrition; pig genome; programs; symposium

DESCRIPTION (provided by applicant): The Swine in Biomedical Research Conference 2011 will highlight the growing utility of swine models in biomedical research. In the toolbox category, genomic and tissue microarrays and next generation sequencing are just beginning to be appreciated. In the applications category, there is still much to explore beyond the pig's already proven value in immunology, nutrition, transplantation, cardiovascular disease, and orthopedics. New initiatives are warranted in zoonotic diseases, cognitive behavior, bioengineering and regenerative medicine. The pig genome has been completed and sequence information can be used to construct models to development new means of diagnosing and treating life style-related diseases. The ability to genetically modify and clone pigs further enhances the value of the pig for dissecting disease mechanisms and validating clinical therapies. Recent workshops have focused on utilizing animal sciences expertise traditionally supported by the USDA can support of NIH funded investigators that utilizing pig models. These joint USDA and NIH discussions identified cultural differences and the lack of in depth knowledge of needs and opportunities as major rate limiting issues. Hence, this conference has been organized to directly address these acknowledged limitations. First, the Organizing Committee has selected individuals whose research has successfully transcended both health and animal science cultures. Second, the invited speakers will showcase investigations using the pig that demonstrate successful applications as well as promising areas that require engagement across the proposed cultural divide. Finally, we will invite USDA and NIH representations to lead discussions on integrating respective strengths into addressing critical biomedical research issues. PUBLIC HEALTH RELEVANCE (provided by applicant): The Swine in Biomedical Research Conference 2011 represents the fourth in a series of timely conferences that have highlighted the utility of porcine models in biomedical research. The emergence of genetic information and the technologies to target manipulations combined with the ability to clone pigs provides the ability to create highly relevant animal model. This conference will build upon the considerable energy within the biomedical community with respect to the utilization of pigs.

描述（由申请人提供）：2011 年猪生物医学研究会议将强调猪模型在生物医学研究中日益增长的实用性。在工具箱类别中，基因组和组织微阵列以及下一代测序才刚刚开始受到重视。在应用领域，除了猪在免疫学、营养、移植、心血管疾病和骨科方面已被证实的价值之外，还有很多值得探索的地方。在人畜共患疾病、认知行为、生物工程和再生医学领域需要采取新的举措。猪基因组已经完成，序列信息可用于构建模型，开发诊断和治疗生活方式相关疾病的新手段。基因改造和克隆猪的能力进一步增强了猪在剖析疾病机制和验证临床治疗方面的价值。最近的研讨会重点关注利用传统上由美国农业部支持的动物科学专业知识，以支持美国国立卫生研究院资助的利用猪模型的研究人员。美国农业部和美国国立卫生研究院的这些联合讨论将文化差异和缺乏对需求和机会的深入了解视为主要的速率限制问题。因此，组织这次会议是为了直接解决这些公认的局限性。首先，组委会选择了其研究成功超越健康和动物科学文化的个人。其次，受邀演讲者将展示使用猪进行的调查，这些调查展示了成功的应用以及需要跨越拟议的文化鸿沟参与的有前途的领域。最后，我们将邀请美国农业部和美国国立卫生研究院的代表主持讨论，以整合各自的优势来解决关键的生物医学研究问题。 公共健康相关性（由申请人提供）：2011 年猪生物医学研究会议是一系列及时会议中的第四次会议，这些会议强调了猪模型在生物医学研究中的实用性。遗传信息和靶向操作技术的出现，再加上克隆猪的能力，提供了创建高度相关的动物模型的能力。这次会议将利用生物医学界在猪的利用方面的大量精力。