CORE--Physiology-Animal

核心--生理学-动物

• 批准号: 7673354
• 负责人: You-Tang Shen
• 金额: $ 54.34万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7673354
• 关键词: Adult; Animal Husbandry; Animal Model; Animals; Breeding; Caring; Chronic; Databases; Echocardiography; Family suidae; Genotype; Goals; Health; Heart Diseases; Housing; Human Resources; Laboratory Animal Production and Facilities; Maintenance; Mus; Muscle Cells; Neonatal; New Jersey; Operative Surgical Procedures; Physiology; Preparation; Rattus; Rodent Model; Services; Surgical Models; Sus scrofa; Transgenic Mice; animal care; cost; feeding; hemodynamics; instrument; medical schools; mouse model

Core B, the Physiology/Animal Care Core, will provide services related to the preparation of animal models used in the PPG including surgical preparation of the various pig, and mouse models and the health maintenance of these chronic animal preparations. Animal husbandry, including normal housing and feeding, will be carried out by the Research Animal Facility of UMDNJ - New Jersey Medical School. There are four major functions of Core B. The first component of Core B involves surgical preparation of the large animal models, which is required for Projects 1 and 2. The second component involves surgical preparation of the rodent models, which is required for Projects 3 and 4. In the third component, Core B will provide the animal care required for the animal models, including both the care required for maintaining health in chronically instrumented animals and maintenance of the breeding colonies of transgenic mice. The fourth function is administration, since this core services all projects and interacts closely with the other cores, and must meet the regulatory requirements for animal care. The breakdown is as follows: Projects 1 and 2 will use domestic swine (25 % of Core activity, but 30% of Core costs, for each project), Project 3 will use transgenic mice (30% of Core activity, but 25% of Core costs) (rats will be used for neonatal and adult myocyte culture), Project 4 will use transgenic mice (20% of Core activity, but 15% of Core costs).

核心 B，生理学/动物护理核心，将提供与动物模型制备相关的服务 PPG包括各种猪、小鼠模型的手术准备以及这些慢性病的健康维持 动物制剂。畜牧业，包括正常的饲养和饲养，将由研究中心进行 UMDNJ - 新泽西医学院的动物设施。 Core B主要有四大功能。 第一个组件 核心 B 涉及大型动物模型的手术准备，这是项目 1 和 2 所必需的。 第 3 部分涉及啮齿动物模型的手术准备，这是项目 3 和 4 所必需的。 组成部分，核心 B 将提供动物模型所需的动物护理，包括 维持长期仪器动物的健康和维持转基因小鼠的繁殖群体。 第四个功能是管理，因为该核心为所有项目提供服务并与其他核心密切交互，并且 必须满足动物护理的监管要求。具体情况如下： 项目1、2将使用 家猪（每个项目占核心活动的 25%，但核心成本占 30%），项目 3 将使用转基因小鼠（30% 核心活动的 25%，但核心成本的 25%）（大鼠将用于新生儿和成人肌细胞培养），项目 4 将使用 转基因小鼠（核心活动的 20%，但核心成本的 15%）。