Improving Effectiveness and Accuracy of Radiation Therapy

提高放射治疗的有效性和准确性

• 批准号: 7575501
• 负责人: Rebecca Maureen Howell
• 金额: $ 13.37万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-24 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7575501
• 关键词: Address; Adverse effects; Algorithms; American Cancer Society; Area; Cancer Etiology; Cancer Patient; Cessation of life; Critiques; Diagnosis; Dose; Effectiveness; Ensure; Goals; Individual; Intensity-Modulated Radiotherapy; Lung; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Measurement; Measures; Methods; Organ; Outcome; Patients; Peripheral; Radiation; Radiation Oncologist; Radiation therapy; Rate; Reaction; Research; Research Methodology; Research Personnel; Skin; Therapeutic; Time; Tissues; Training Activity; United States; Work; anticancer research; base; cancer radiation therapy; cancer type; density; dosage; improved; interest; men; prescription document; prescription procedure; size

DESCRIPTION (provided by applicant): Introduction: Effectiveness of radiation therapy can be improved through increased accuracy in radiotherapy calculations. The proposed research will focus on two types of cancer, prostate and lung. The proposed prostate cancer research is an extension of earlier work while the lung cancer research is a new area of interest. Background: Treatment for prostate cancer is successful in most cases. Although 1 in 8 men will be diagnosed with prostate cancer, only 1 in 34 will die from prostate cancer (American Cancer Society). Research proposed in Specific Aims 1 and 2 focuses on decreasing adverse radiation side-effects by increasing the understanding of dose distributions and side effects from Intensity Modulated Radiation therapy (IMRT) for prostate cancer. The goal of this project is to provide Radiation Oncologists the necessary information to select the most appropriate beam energy for individual patients. Lung cancer is the leading cause of cancer death in the United States, approximately 6 out of 10 people with lung cancer die within 1 year of being diagnosed (American Cancer Society). Improving the therapeutic gains in lung cancer is imperative. Specific Aims 3 and 4 focus on improving the accuracy of dose calculations in lung cancer radiation therapy with the long term goal of understanding how much radiation dose is necessary to increase cure rates. Hypothesis: Increased accuracy in radiotherapy dose calculations can reduce adverse side effects from prostate cancer radiotherapy and can increase the therapeutic gain for lung cancer radiotherapy. Specific Aims: The following research aims will be addressed: (1) Perform skin dose measurements to evaluate skin reactions for prostate cancer patients treated with 6MV beam energy for IMRT; (2) Perform Monte Carlo calculations (in phantom) of dose to peripheral organs from IMRT, expandable to individual patient calculations; three years of protected time to facilitate her transition to an established cancer researcher. Her research plan is based on her previous work in improving the quantification of dosage effects for intensity-modulated radiotherapy (IMRT). The previous submission was primarily critiqued for lack of a full breadth of training activities and for brevity of research methods including a lack of statistical analyses methods and justification.

描述（由申请人提供）： 简介：可以通过提高放射治疗计算的准确性来提高放射治疗的有效性。拟议的研究将重点关注两种类型的癌症：前列腺癌和肺癌。拟议的前列腺癌研究是早期工作的延伸，而肺癌研究是一个新的兴趣领域。背景：前列腺癌的治疗在大多数情况下都是成功的。尽管八分之一的男性会被诊断出患有前列腺癌，但只有三分之一的男性会死于前列腺癌（美国癌症协会）。具体目标 1 和 2 中提出的研究重点是通过增加对前列腺癌调强放射治疗 (IMRT) 的剂量分布和副作用的了解来减少不良放射副作用。该项目的目标是为放射肿瘤学家提供必要的信息，以便为个体患者选择最合适的射束能量。肺癌是美国癌症死亡的主要原因，大约十分之六的肺癌患者在诊断后 1 年内死亡（美国癌症协会）。提高肺癌的治疗效果势在必行。具体目标 3 和 4 侧重于提高肺癌放射治疗剂量计算的准确性，长期目标是了解提高治愈率需要多少辐射剂量。 假设：提高放射治疗剂量计算的准确性可以减少前列腺癌放射治疗的不良副作用，并可以增加肺癌放射治疗的治疗增益。具体目标：将解决以下研究目标：（1）进行皮肤剂量测量，以评估接受 6MV 束能量 IMRT 治疗的前列腺癌患者的皮肤反应； (2) 对调强放射治疗 (IMRT) 外周器官的剂量进行蒙特卡罗计算（以模型形式），可扩展到个体患者计算；三年的受保护时间，以帮助她过渡到一名成熟的癌症研究员。她的研究计划基于她之前在改进调强放射治疗 (IMRT) 剂量效应量化方面的工作。先前提交的材料主要因缺乏全面的培训活动和研究方法的简洁性（包括缺乏统计分析方法和理由）而受到批评。