Consortium to improve OutcoMes in HIV/Aids, Alcohol, Aging & multi-Substance use

联盟致力于改善艾滋病毒/艾滋病、酒精和老龄化方面的结果

• 批准号: 8211467
• 负责人: Amy Caroline Justice
• 金额: $ 77.72万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8211467
• 关键词: AIDS/HIV problem; Address; Aging; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Authorship; Caring; Cataloging; Catalogs; Centers for Disease Control and Prevention (U.S.); Clinic; Cohort Studies; Collaborations; Color; Consent; Data; Data Analyses; Data Collection; Dependence; Development; Discipline; Education; Enrollment; Ensure; Europe; Funding; Future; Goals; Grant; HIV; HIV Infections; Healthcare; Hepatitis C; Hepatitis C virus; Individual; Information Technology; Intervention; Intervention Studies; Intervention Trial; Knowledge; Laboratories; Leadership; Medical center; Mental Depression; Mission; Modeling; Monitor; National Institute on Alcohol Abuse and Alcoholism; New York; North America; Observational Study; Online Systems; Operations Research; Outcome; Patients; Persons; Policy Maker; Positioning Attribute; Procedures; Public Health; Publications; Registries; Research; Research Design; Research Personnel; Resources; Risk; Role; Sampling; Site; Study Subject; Subgroup; System; Target Populations; Testing; Training and Education; United States Department of Veterans Affairs; Update; Validation; Veterans; Woman; Work; alcohol effect; alcohol intervention; alcohol misuse; alcohol research; base; behavioral health; career development; clinical care; cohort; design; experience; improved; insight; men who have sex with men; middle age; models and simulation; operation; programs; virtual

DESCRIPTION (provided by applicant): The Veterans Aging Cohort Study (VACS) is the largest HIV cohort in the North America (40,594). It includes a nested, consented 8 site sample (VACS 8) of 3,660 HIV infected (HIV+) veterans demographically matched to 3652 uninfected veterans (HIV-) which has longitudinal in-depth data spanning nearly 10 years on alcohol, substance use, and health and behavioral outcomes. Of the HIV+ subjects in VACS 8, 63% drink alcohol and 32% have unhealthy alcohol use. Because VACS includes uninfected comparators, we are able to characterize the role of HIV infection in alcohol associated outcomes. VACS include large well characterized samples of understudied, but important subgroups: middle aged and older individuals, people of color, Black men who have sex with men, those with HCV infection (HCV+). We propose to enroll more women and those new to care. We have conducted observational research, and limited operations modeling and intervention studies within VACS focused on the role of alcohol in determining modifiable outcomes among HIV+/-. We have a national network of investigators and a highly effective Coordinating Center at the West Haven VA Medical Center. Our group has produced >100 widely cited, publications. We are proud of the education and career development support we have offered, but VACS funding for alcohol research ends September 2011. We propose to transform VACS into the Consortium to improve OutcoMes in HIV/Aids, Alcohol, Aging, and multi-Substance use (COMpAAAS) by 1) expanding our work in intervention and operations modeling while maintaining excellence in observational data analyses, 2) Converting our clinic based observational study into an Interactive Web Based Laboratory and providing administrative and methodological support to our network of investigators, and 3) Tapping our network of collaborators in North America and Europe to validate and extend our findings. Our consortium mission is to incrementally build and disseminate the evidence needed to optimize health care for HIV+ harmed by alcohol, multisubstance use, HCV, and depression through strategically coordinated, integrated, and externally validated observation, operations modeling, and intervention studies. PUBLIC HEALTH RELEVANCE: We propose to organize a collaboration of research experts, clinicians, patients, and policy makers into the Consortium to improve OutcoMes in HIV/AIDS (COMpAAAS). Our mission is to provide new knowledge to improve the health care of HIV infected persons harmed by alcohol and related conditions (multisubstance use, HCV, and depression) through insights from observation, intervention, and simulation modeling.

描述（由申请人提供）：退伍军人老化队列研究（VACS）是北美最大的艾滋病毒队列（40,594）。它包括3,660名HIV感染的（HIV+）退伍军人的嵌套，同意的8个现场样本（VAC 8），该样本在人口统计学上与3652名未感染的退伍军人（HIV-）相匹配，该人的纵向深入数据涵盖了近10年的酒精，物质使用，健康以及健康和行为和行为和行为和行为和行为和行为和行为均具有近10年的范围。在VACS中的HIV+受试者中，有63％的酒精和32％的酒精使用不健康。由于VACS包括未感染的比较器，因此我们能够表征HIV感染在酒精相关结果中的作用。 VACS包括大量良好特征的研究，但研究了重要的亚组：中年和老年人，有色人种，与男性发生性关系的黑人，患有HCV感染的人（HCV+）。我们建议招募更多的妇女和新手的妇女。我们已经进行了观察性研究，并在VAC中进行了有限的操作建模和干预研究，该研究集中在酒精在确定HIV +/-之间可改变的结果中的作用上。我们在West Haven VA医疗中心拥有一个国家调查人员网络和一个高效的协调中心。我们的小组制作了> 100个广泛引用的出版物。 We are proud of the education and career development support we have offered, but VACS funding for alcohol research ends September 2011. We propose to transform VACS into the Consortium to improve OutcoMes in HIV/Aids, Alcohol, Aging, and multi-Substance use (COMpAAAS) by 1) expanding our work in intervention and operations modeling while maintaining excellence in observational data analyses, 2) Converting our clinic based observational study into an Interactive Web Based实验室并为我们的研究人员网络提供行政和方法学支持，以及3）利用我们在北美和欧洲的合作者网络来验证和扩展我们的发现。我们的财团使命是通过策略性地协调，综合和外部验证的观察，操作建模和干预研究来逐步构建和传播对艾滋病毒+优化艾滋病毒+损害的医疗保健所需的证据。 公共卫生相关性：我们建议组织研究专家，临床医生，患者和政策制定者的合作，以改善艾滋病毒/艾滋病的结果（Compaaaas）。我们的任务是提供新知识，以通过观察，干预和模拟建模的见解来改善受酒精和相关条件（多进取的使用，HCV和抑郁症）伤害的艾滋病毒感染者的医疗保健。