Developing appropriate risk reduction interventions for pre-teens

为青春期前的青少年制定适当的降低风险干预措施

• 批准号: 7337220
• 负责人: Glenda E Gray
• 金额: $ 19.7万
• 依托单位: WITS HEALTH CONSORTIUM (PTY), LTD
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-08 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7337220
• 关键词: 15 year old; 18 year old; 19 year old; AIDS prevention; AIDS/HIV problem; Accounting; Acquired Immunodeficiency Syndrome; Address; Adolescent; Africa South of the Sahara; Age; Age-Years; Area; Attitude; Awareness; Behavior; Biological Models; Centers for Disease Control and Prevention (U.S.); Childhood; Clinical Trials Network; Coercion; Cognitive; Cohort Studies; Communities; Counseling; Data; Development; Disclosure; Disease; Dose; Ecosystem; Effectiveness; Enrollment; Ethnography; Focus Groups; Funding; Future; Goals; HIV; HIV Infections; HIV vaccine; Household; Human immunodeficiency virus test; Incidence; Intention; International; Intervention; Interview; Legal; Licensure; Modeling; National Institute of Mental Health; Participant; Phase; Population; Prevalence; Prevention; Prevention program; Purpose; Questionnaires; Randomized; Rate; Readiness; Research; Risk; Risk Assessment; Risk Behaviors; Risk Reduction; Risk Reduction Behavior; Safety; Sampling; Seroprevalences; Sex Behavior; Sexuality; Site; Social Network; Societies; South Africa; Stigmata; Surveys; Techniques; Teenagers; Testing; Urbanization; Ursidae Family; Vaccines; Woman; Youth; age group; aged; base; behavior change; cohort; concept; efficacy trial; family structure; girls; immunogenicity; information gathering; man; programs; skills; social stigma; tool; young adult

DESCRIPTION (provided by applicant): More than half of all new HIV infections occur in young people below the age of 24 years. In sub-Saharan Africa, young women bear the burden of HIV disease. In South Africa, current HIV prevention programs have not impacted on behavior change despite high levels of HIV/AIDS awareness. This may be attributed to the marked changes in society seen since the transition from apartheid with concomitant rapid rates of urbanization, disintegration of family structures, and a general lack of understanding of adolescent sexuality, current youth attitudes and practices, as well as prevention messages that are not context specific. Strategies are required to successfully test HIV preventative vaccines in pre-teens and adolescents. Currently, there are two promising HIV vaccine candidates that are being tested in phase IIb or proof of concept trials, and adolescent involvement in one of these trials is imminent. The purpose of this exploratory research is to develop and validate a cultural- and age-appropriate risk reduction counseling intervention for pre-teens and adolescent HIV vaccine trial participants. Strategies are required to successfully test HIV preventative vaccines in pre-teens and adolescents. Currently, there are two promising HIV vaccine candidates that are being tested in phase IIb or "test of concept" trials, and adolescent involvement in one of these trials is imminent. The purpose of this exploratory research is to develop and validate a culturally and developmentally appropriate risk reduction counseling intervention for pre-teens and adolescent HIV vaccine trial participants.

描述（由申请人提供）：超过一半的新发 HIV 感染发生在 24 岁以下的年轻人中。在撒哈拉以南非洲地区，年轻女性承受着艾滋病毒的负担。在南非，尽管艾滋病毒/艾滋病意识水平很高，但目前的艾滋病毒预防计划并未对行为改变产生影响。这可能归因于自种族隔离过渡以来社会发生的显着变化，伴随着城市化的快速发展、家庭结构的解体以及对青少年性行为、当前青少年态度和做法以及预防信息普遍缺乏了解。不是特定于上下文的。需要制定策略来成功测试青春期前和青少年的艾滋病毒预防疫苗。目前，有两种有前途的艾滋病毒候选疫苗正在 IIb 期或概念验证试验中进行测试，青少年即将参与其中一项试验。这项探索性研究的目的是为青春期前和青少年艾滋病毒疫苗试验参与者开发和验证适合文化和年龄的风险降低咨询干预措施。 需要制定策略来成功测试青春期前和青少年的艾滋病毒预防疫苗。目前，有两种有前途的艾滋病毒候选疫苗正在 IIb 期或“概念测试”试验中进行测试，青少年即将参与其中一项试验。这项探索性研究的目的是为青春期前和青少年艾滋病毒疫苗试验参与者开发和验证一种适合文化和发展的风险降低咨询干预措施。