Tools for Optimizing Medication Safety (TOP-MEDS)

优化用药安全的工具 (TOP-MEDS)

• 批准号: 8265048
• 负责人: BRUCE L. LAMBERT
• 金额: $ 84.88万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8265048
• 关键词: Tools; Optimizing; Medication; Safety; TOP

DESCRIPTION (provided by applicant): We propose a patient safety CERT focused on the theme of Tools for Optimizing Medication Safety (TOPMEDS). The long term goal is to improve patient safety by developing and refining tools for safer medication use. The short term objective is to develop, test, deploy and disseminate tools and training materials in four key areas: statistical methods for large-scale studies of comparative drug safety and effectiveness, opioid prescribing and dosing for acute pain, methods for preventing and detecting drug name confusion errors, and patient-centered, language concordant drug information. We will carry out studies with the following specific aims: 1. Develop and apply a multivariate, person-time logistic regression model for large-scale adverse drug event screening. 2. Improve the safety and effectiveness of inpatient acute pain care by developing and validating a novel, web-based simulator to train prescribers in the proper selection and dosing of opioids. 3. Refine a standard battery of tests for pre-market safety screening of drug names, and develop and test methods for preventing and detecting drug name confusion errors using electronic medical records. 4. Rigorously evaluate a low literacy strategy for promoting safe and effective prescription medication use among English and Spanish-speaking patients in an urban primary care setting. Together the projects address all five of the programmatic interest areas: comparative effectiveness, patient safety, development of tools, health care system interventions, and translation into policy or practice. UIC will host the center, with collaborators at Rush Universit Medical Center, Northwestern University, University of Chicago, the Brigham and Women's Hospital, Discerning Systems, Inc., the Institute for Safe Medication Practices, and the National Patient Safety Foundation. Our investigators are national and international leaders in statistics (Robert Gibbons), health literacy (Michael Wolf), drug name confusion (Bruce Lambert), health information technology (Gordon Schiff, Bill Galanter), pain care (Robert McNutt and Diana Wilkie) medication error prevention (Michael Cohen) and patient safety (Tim McDonald, Diane Pinakiewicz). PUBLIC HEALTH RELEVANCE: Patients are not as safe as they should be. Medication errors and inappropriate use of medicines, by health professionals and patients, cause a great deal of harm. The proposed research will make patients safer by developing and sharing tools for safer medication use, including tools for detecting drug risks, for training young doctors, for preventin medication errors and for making drug information easier to understand.

描述（由申请人提供）：我们提议建立一个患者安全 CERT，重点关注优化用药安全工具 (TOPMEDS) 的主题。长期目标是通过开发和完善更安全用药的工具来提高患者安全。短期目标是在四个关键领域开发、测试、部署和传播工具和培训材料：比较药物安全性和有效性的大规模研究的统计方法、急性疼痛的阿片类药物处方和剂量、预防和检测药物的方法名称混淆错误，以及以患者为中心、语言一致的药物信息。我们将开展以下具体目标的研究： 1. 开发和应用多元、人时物流 用于大规模药物不良事件筛查的回归模型。 2. 通过开发和验证一种新颖的基于网络的模拟器来培训处方者正确选择和服用阿片类药物，提高住院急性疼痛护理的安全性和有效性。 3.完善药品上市前安全筛查测试标准体系，开发和测试利用电子病历预防和检测药品名称混淆错误的方法。 4. 严格评估低识字率策略，以促进城市初级保健环境中英语和西班牙语患者安全有效地使用处方药。这些项目共同解决了所有五个计划利益领域：比较有效性、患者安全、工具开发、医疗保健系统干预以及转化为政策或实践。 UIC 将主办该中心，合作者包括拉什大学医学中心、西北大学、芝加哥大学、布莱根妇女医院、Discerning Systems, Inc.、安全用药实践研究所和国家患者安全基金会。我们的调查员是统计学（罗伯特·吉本斯）、健康素养（迈克尔·沃尔夫）、药物名称混淆（布鲁斯·兰伯特）、健康信息技术（戈登·希夫、比尔·加兰特）、疼痛护理（罗伯特·麦克纳特和戴安娜·威尔基）药物领域的国内和国际领导者错误预防（Michael Cohen）和患者安全（Tim McDonald、Diane Pinakiewicz）。 公共卫生相关性：患者并不像应有的那样安全。卫生专业人员和患者的用药错误和药物使用不当会造成很大的伤害。拟议的研究将通过开发和共享更安全的用药工具，包括检测药物风险、培训年轻医生、预防用药错误以及使药物信息更容易理解的工具，使患者更安全。