CHLAMYDIA VACCINE STUDIES IN THE PIGTAIL MACAQUE

辫尾猕​​猴的衣原体疫苗研究

• 批准号: 8172771
• 负责人: DOROTHY L PATTON
• 金额: $ 15.51万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172771
• 关键词: Adjuvant; Chlamydia; Chlamydia Infections; Chlamydia trachomatis; Computer Retrieval of Information on Scientific Projects Database; Funding; Future; Goals; Grant; HIV; Infertility; Institution; Macaca; Macaca nemestrina; Modeling; Phase; Research; Research Design; Research Personnel; Resources; Sexually Transmitted Diseases; Source; Testing; United States National Institutes of Health; Vaccines; arm; pre-clinical; prevent; vaccine candidate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term goal of this project is to explore the efficacy of vaccine candidates targeting chlamydial infection. Chlamydia trachomatis is a common sexually transmitted disease which is largely asymptomatic, can progress to infertility and has been associated with the facilitated acquisition of other STIs including HIV. The initial phases of this study will focus on determining an appropriate positive control to utilize in future preclinical vaccine studies to be carried out in the macaque model. With the determination of an appropriate positive control, further studies will be conducted in three- to four-arm study designs (test product; positive control; negative control; adjuvant control), where vaccine products can be developed to prevent chlamydial infection and subsequent sequelae.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目的长期目标是探索针对衣原体感染的疫苗候选者的功效。 沙眼衣原体是一种常见的性传播疾病，在很大程度上是无症状的，可以发展为不育，并且与包括HIV在内的其他性传播感染的促进。 这项研究的初始阶段将着重于确定在猕猴模型中要进行的未来临床前疫苗研究中使用的适当阳性对照。通过确定适当的阳性对照，将在三到四臂研究设计（测试产物；阳性对照；阴性对照；辅助对照）中进行进一步的研究，其中可以开发疫苗以防止衣原体感染和后续后遗症。