T CELL MARKERS IN HCV RECHALLENGE OF CHIMPANZEES: ASSOCIATION WITH CLEARANCE

黑猩猩 HCV 再次攻击中的 T 细胞标记：与清除的关联

• 批准号: 8172691
• 负责人: Marian Major
• 金额: $ 0.53万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172691
• 关键词: American; Biological Markers; Cells; Cessation of life; Chronic; Cirrhosis; Computer Retrieval of Information on Scientific Projects Database; Funding; Future; Grant; HCV Vaccine; Hepatitis C; Hepatitis C virus; Individual; Infection; Institution; Lead; Liver; Liver diseases; Mediating; Pan Genus; Primary carcinoma of the liver cells; Research; Research Personnel; Resources; Source; T cell response; T memory cell; T-Lymphocyte; United States National Institutes of Health; Vaccines; Virus; Virus Diseases; prevent; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hepatitis C Virus results in persistent infections in over 70% of infected individuals. Chronic infections often lead to chronic liver disease, cirrhosis and hepatocellular carcinoma. Of the nearly 3 million Americans infected with HCV, there are about 10,000 deaths each year due to liver complications. There is presently no vaccine to prevent HCV infections. It is believed that T lymphocytes are responsible for clearing HCV infections in those who are able to control the virus before it becomes persistent. In previous chimpanzee experiments, we have shown that acutely infected chimpanzees that naturally clear the infection can be re-infected by an identical virus. This second infection is quickly controlled and the virus rapidly cleared. We have also shown that this control is mediated by rapid expansion of HCV-specific memory T-cells. We wish to qualitatively analyze the recall T-cell response in recovered rechallenged chimpanzees so that biomarkers can be established to determine if developed T-cell vaccines will be effective at preventing viral disease. The results of this study will greatly reduce the use of chimpanzees for future experimentation and enhance the efficacy of HCV vaccines.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 丙型肝炎病毒导致超过70％的感染个体持续感染。 慢性感染通常会导致慢性肝病，肝硬化和肝细胞癌。 在感染HCV的近300万美国人中，由于肝脏并发症，每年大约有10,000人死亡。 目前没有疫苗可以防止HCV感染。 据信，T淋巴细胞负责清除能够控制该病毒的人的HCV感染。 在先前的黑猩猩实验中，我们表明，自然而然地清除感染的急性感染的黑猩猩可以被相同的病毒重新感染。 第二种感染很快受到控制，病毒迅速清除。 我们还表明，该控制是由HCV特异性内存T细胞快速扩展介导的。 我们希望定性地分析回收后的黑猩猩中的回忆T细胞反应，以便可以建立生物标志物，以确定开发的T细胞疫苗是否有效预防病毒疾病。 这项研究的结果将大大减少黑猩猩的未来实验，并提高HCV疫苗的功效。