USE OF AN ORGANOPHOSPHORUS (OP) HYDROLASE FOR ACUTE OP TOXICITY

使用有机磷 (OP) 水解酶治疗急性 OP 毒性

• 批准号: 8172874
• 负责人: STEVEN B BIRD
• 金额: $ 6.58万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172874
• 关键词: Acute; Computer Retrieval of Information on Scientific Projects Database; Dichlorvos; Enzymes; Funding; Grant; Human Development; Hydrolase; Institution; Modeling; Parathion; Pesticides; Poisoning; Research; Research Personnel; Resources; Source; Toxic effect; United States National Institutes of Health; improved; novel; safety testing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this grant is and to test the safety and efficacy of a novel organophosphorus pesticide degrading enzyme, OpdA, in an NHP model. Proof that the enzyme is safe and effective against parathion and dichlorvos should provide the necessary impetus for further development for human use. Our central hypothesis is that OpdA is safe and improves survival after poisoning with parathion and dichlorvos.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这笔赠款的目的是，并在NHP模型中测试一种新型有机磷的农药降解酶的安全性和功效。证明该酶是安全有效地抵抗Parathion和Dichlorvos的证明，应为进一步开发人类使用提供必要的动力。我们的中心假设是OPDA是安全的，可以改善Parathion和Dichlorvos中毒后的生存。