IN UTERO STEM CELL TRANSPLANTATION IN PRIMATES

灵长类动物子宫内干细胞移植

• 批准号: 8172755
• 负责人: ROBERT GOFF ANDREWS
• 金额: $ 15.51万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172755
• 关键词: Adult; Computer Retrieval of Information on Scientific Projects Database; Engraftment; Fetus; Funding; Grant; Hematopoietic stem cells; Immune; Immunologics; Institution; Natural Killer Cells; Play; Pregnancy; Primates; Research; Research Personnel; Resources; Role; Source; Stem cell transplant; United States National Institutes of Health; adult stem cell; improved; in utero; mature animal

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this project is to explore the role of Natural Killer (NK) cells in promoting in utero engraftment by adult hematopoietic stem cells. NK cells play a role in overcoming immunologic barriers to hematopoietic stem cell engraftment in adult animals. We have demonstrated that immunologic barriers are present in the fetus that can interfere with engraftment of adult stem cells early in gestation. We are examining the ability of adult NK cells to overcome these immune barriers and improve in utero engraftment by adult hematopoietic stem cells.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目的目的是探索自然杀伤（NK）细胞在促进成体造血干细胞在子宫内植入中的作用。 NK 细胞在克服成年动物造血干细胞植入的免疫障碍方面发挥着重要作用。 我们已经证明，胎儿中存在免疫屏障，可能会干扰妊娠早期成体干细胞的植入。 我们正在研究成体 NK 细胞克服这些免疫屏障并改善成体造血干细胞在子宫内植入的能力。