IN UTERO STEM CELL TRANSPLANTATION IN PRIMATES

灵长类动物子宫内干细胞移植

• 批准号: 8172755
• 负责人: ROBERT GOFF ANDREWS
• 金额: $ 15.51万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172755
• 关键词: Adult; Computer Retrieval of Information on Scientific Projects Database; Engraftment; Fetus; Funding; Grant; Hematopoietic stem cells; Immune; Immunologics; Institution; Natural Killer Cells; Play; Pregnancy; Primates; Research; Research Personnel; Resources; Role; Source; Stem cell transplant; United States National Institutes of Health; adult stem cell; improved; in utero; mature animal; Adult; Computer Retrieval of Information on Scientific Projects Database; Engraftment; Fetus; Funding; Grant; Hematopoietic stem cells; Immune; Immunologics; Institution; Natural Killer Cells; Play; Pregnancy; Primates; Research; Research Personnel; Resources; Role; Source; Stem cell transplant; United States National Institutes of Health; adult stem cell; improved; in utero; mature animal

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this project is to explore the role of Natural Killer (NK) cells in promoting in utero engraftment by adult hematopoietic stem cells. NK cells play a role in overcoming immunologic barriers to hematopoietic stem cell engraftment in adult animals. We have demonstrated that immunologic barriers are present in the fetus that can interfere with engraftment of adult stem cells early in gestation. We are examining the ability of adult NK cells to overcome these immune barriers and improve in utero engraftment by adult hematopoietic stem cells.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目的目的是探索自然杀手（NK）细胞在成年造血干细胞促进子宫内植入子宫内的作用。 NK细胞在克服成年动物造血干细胞植入的免疫障碍中起作用。 我们已经证明，胎儿存在免疫屏障，可以在妊娠早期植入成年干细胞。 我们正在研究成年NK细胞克服这些免疫屏障并改善成年造血干细胞子宫内植入的能力。