VISUALIZATION AND VISUAL WORKFLOW ENVIRONMENT TO ENHANCE MULTI-SCALE MODELING

可视化和可视化工作流程环境增强多尺度建模

• 批准号: 8169338
• 负责人: MICHEL F. SANNER
• 金额: $ 26.8万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169338
• 关键词: Area; Automation; Biological; Biomedical Research; Communities; Complex; Computational Biology; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Electron Microscopy; Environment; Funding; Future; Genes; Genome; Goals; Grant; Image; Imagery; Individual; Institution; Internet; Lead; Modeling; Molecular Structure; Network-based; Physics; Research; Research Infrastructure; Research Personnel; Resources; Sampling; Scientist; Services; Source; Structure; Structure-Activity Relationship; United States National Institutes of Health; Vision; Visual; Work; base; design; flexibility; functional genomics; graphical user interface; light microscopy; meetings; multi-scale modeling; novel; programs; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this research is to develop a component-based visualization environment that is useful to a broad range of biological scientists working on aspects of molecular structure function relationships at various scales and with a variety of data types. The environment supports structural information that ranges from gene sequence and structure at atomic detail, to data reconstructed from electron microscopy, and light microscopy. As the Genome Initiative expands into the area of functional genomics, there is an increasing need for visualization tools that integrate data and computation from across the biophysical range. The possibility of developing complex models from sequence data, individual molecular structures, and imaging of biological samples will depend upon computational and visualization environments that support multi-modal and multi-scale capabilities. By capitalizing on the component-based interaction infrastructure, we will be able to efficiently and effectively design and build visualization tools that are tailored to the growing needs of the computational biology community, and that will integrate into network based computational and collaborative environments. The overall objective of this project is to provide the biomedical community with powerful and flexible Graphical User Interfaces (GUIs) and visual tools that will facilitate the rapid development, reconfiguration and novel utilization of multi-scale, multi-physics models and applications for biomedical research. In order to meet this goal, we will harden, extend, and deploy component-based, interactive environments for biomedical programming, computation, analysis, and visualization. A special emphasis will be put on the automation of interfacing new tools to this environment, supporting large and complex workflows, integrating web services, and batch executions of computational workflows. The overall progress of Aims 1, 2 and 3 have somewhat been hampered by the departure of Guillaume Vareille who has been the lead developer of our workflow environment: Vision and our 3D visualization component: DejaVu, for the past 4 years. Dr. Sanner will assume this responsibility in the immediate future. Despite this setback, substantial progress has been achieved.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是开发一个基于组件的可视化环境，该环境对各个尺度和各种数据类型的分子结构功能关系的广泛生物学家有用。环境支持从原子细节的基因序列和结构到从电子显微镜重建的数据和光学显微镜的结构信息。随着基因组倡议的扩展 功能基因组学领域，对可视化工具的需求越来越多，可以整合来自生物物理范围的数据和计算。从序列数据，单个分子结构以及生物样品成像开发复杂模型的可能性将取决于支持多模式和多尺度功能的计算和可视化环境。通过利用基于组件的交互基础架构，我们将能够高效地设计和构建根据计算生物学社区不断增长的需求量身定制的可视化工具，并将集成到基于网络的计算和协作环境中。 该项目的总体目的是为生物医学界提供强大而灵活的图形用户界面（GUI）和视觉工具，以促进对生物医学研究的多规模，多物理模型和应用程序的快速开发，重新配置和新颖利用。为了实现此目标，我们将硬化，扩展和部署基于组件的交互式环境，用于生物医学编程，计算，分析和可视化。将新工具与该环境接口，支持大型且复杂的工作流程，集成Web服务以及计算工作流程的批处理执行。 AIM 1、2和3的总体进步受到了Guillaume Vareille的离开的阻碍，后者一直是我们工作流环境的主要开发人员：Vision和我们的3D可视化组成部分：Dejavu：Dejavu，在过去的四年中。 Sanner博士将在不久的将来承担这一责任。尽管有这种挫折，但仍取得了很大的进步。