MARKEY CENTER FOR STRUCTURAL BIOLOGY, PURDUE UNIVERSITY

普渡大学马基结构生物学中心

• 批准号: 8172019
• 负责人: Barbara Lynn Golden
• 金额: $ 0.36万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172019
• 关键词: Biological Process; Computer Retrieval of Information on Scientific Projects Database; Data; Data Collection; Funding; Goals; Grant; Hour; Institution; Joints; Laboratories; Laboratory Finding; Learning; Photons; Postdoctoral Fellow; Research; Research Personnel; Resources; Science; Source; Students; Synchrotrons; Training; United States National Institutes of Health; Universities; Work; X-Ray Crystallography; base; beamline; graduate student; improved; operation; programs; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Within the Markey Center for Structural Biology at Purdue University, there are nine groups using X-ray crystallography to understand the structural basis of a wide variety of biological processes. As a group, we would like to submit a joint proposal to gain access to the Advanced Photon Source beamlines. The goals of this proposal are to 1) make maximal use of the APS resource and 2) provide training to graduate students and postdoctoral fellows. Crystallographic data collection has become quite rapid, especially at synchrotron sources. As a result, many laboratories, especially the smaller laboratories, find it difficult to completely fill a 24 hour shift at a beamline. To conserve this valuable resource, we submit this program proposal that will allow the groups at Purdue to split shifts at APS. This mode of operation has the added advantage of having students and postdoctoral fellows from various laboratories working together to collect their data. This will facilitate an exchange of information and ideas, and thereby improve the quality of the science and provide an excellent learning opportunity for our student and postdoctoral trainees. Participating PIs in this submission are: Jue Chen, William Cramer, Barbara Golden, Michael Rossmann, Cynthia Stauffacher, Joe Kappock and Dinesh Yernool. Please see attached pdf for descriptions of representative projects and progress from the previous GUP proposal.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 在普渡大学的Markey结构生物学中心中，有9组使用X射线晶体学来了解各种生物学过程的结构基础。作为一个小组，我们想提交一项联合建议，以访问高级光子源束线。该提案的目标是1）最大程度地利用APS资源，2）为研究生和博士后研究员提供培训。晶体学数据收集变得非常迅速，尤其是在同步加速器来源。结果，许多实验室，尤其是较小的实验室，发现很难在梁线上完全填充24小时的轮班。为了节省这一宝贵的资源，我们提交了该计划建议，该提案将使普渡大学的小组在APS上分裂。这种操作模式具有额外的优势，即来自各种实验室的学生和博士后研究员共同努力收集他们的数据。这将促进信息和思想的交流，从而提高科学的质量，并为我们的学生和博士后学员提供出色的学习机会。参与此提交的PI是：Jue Chen，William Cramer，Barbara Golden，Michael Rossmann，Cynthia Stauffacher，Joe Kappock和Dinesh Yernool。 有关代表性项目的描述以及以前的GUP提案的进展，请参见附带的PDF。