FEASIBILITY STUDY OF DETECTION OF CERVICAL DYSPLYSIA

宫颈发育不良检测的可行性研究

• 批准号: 8170399
• 负责人: CORINE K LAU
• 金额: $ 0.95万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170399
• 关键词: Area; Cervical; Cervix Uteri; Computer Retrieval of Information on Scientific Projects Database; Detection; Diffuse; Dysplasia; Feasibility Studies; Fluorescence; Funding; Grant; Image; Institution; Light; Measures; Modeling; Property; Research; Research Personnel; Resources; Site; Source; Spectrum Analysis; Squamous intraepithelial lesion; System; Tissues; United States National Institutes of Health; absorption; in vivo

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are using Quantitative Spectroscopy (QS) to detect dysplasia in the uterine cervix in vivo. We have developed the Quantitative Spectroscopy Imaging (QSI) system to collect 441 reflectance and fluorescence spectra in vivo over a 2.1cm x 2.1cm area. Each reflectance spectrum is analyzed using a model of diffuse light propagation to give information about the scattering and absorption properties of the tissue. Each fluorescence spectrum is corrected by the measured reflectance spectrum from the same tissue site to correct for turbidity effects. The resulting intrinsic fluorescence spectra are linearly decomposed to give information about the fluorescence properties of the tissue. Measured scattering, absorption, and fluorescence from each tissue site are used to identify high-grade squamous intraepithelial lesions (HSIL) in the cervix.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们正在使用定量光谱（QS）来检测体内子宫颈的发育不良。我们已经开发了定量光谱成像（QSI）系统，以在2.1厘米x 2.1厘米面积的体内收集441反射率和荧光光谱。使用弥漫光传播模型分析每个反射频谱，以提供有关组织的散射和吸收特性的信息。每个荧光光谱都通过从相同组织部位的测得的反射光谱校正，以纠正浊度效应。所得的固有荧光光谱线性分解，以提供有关组织的荧光特性的信息。每个组织部位的测得的散射，吸收和荧光用于识别子宫颈中高级鳞状上皮内病变（HSIL）。