CFD SIMULATION OF AIRFLOW AND AEROSOL TRANSPORT IN HUMAN ALVEOATED AIRWAYS

人体肺泡气道中气流和气溶胶输送的 CFD 模拟

• 批准号: 8171782
• 负责人: BAOSHUN MA
• 金额: $ 0.11万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171782
• 关键词: Aerosols; Arts; Awareness; Biological Warfare; Breathing; Computer Retrieval of Information on Scientific Projects Database; Computer software; Computers; Data; Drug Delivery Systems; Environment; Exposure to; Funding; Grant; Health; High Performance Computing; Human; Institution; Knowledge; Licensing; Link; Liquid substance; Lung; Particulate Matter; Performance; Production; Research; Research Personnel; Resources; Simulate; Source; Supercomputing; United States National Institutes of Health; computing resources; experience; interest; simulation; three-dimensional modeling

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this proposal is to use the high performance computing (HPC) resources and computational fluid dynamics (CFD) software at SDSC to simulate the airflow and aerosol transport in human airways. There have been extensive evidences linking the exposure to particulate matter in environment to human health. The increasingly awareness of biological warfare and the increasing use of inhalation drug delivery also emphasize the need to better understand the fate of inhaled aerosols in the human lung. In the past a majority of studies on aerosol transport in the human lung have focused on the upper and large airways. Data on alveolated small airways have been very limited, and for those existing studies there are serious limitations such as assumption of rigid wall, 2D geometry, or no bifurcation. Our research group at UCSD has recently developed preliminary state-of-the-art models of three-dimensional, alveolated, and bifurcated airways with compliant walls. Initial simulations using a desktop computer have produced some interesting and important results. However, the computing power of the desktop computer seriously limits the efficient production of realistic and highly significant results. Therefore, we propose to use the computing resources at SDSC to help realize our research objectives. The PI of this proposal has more than three years of extensive knowledge of using CFD software (Fluent) with HPC resources at another supercomputing center, focusing on a related project as the current one. In this project we plan to continue to use Fluent software, which was already installed on SDSC computers and licenses are currently available. In the previous experience with the software very good parallel performance has been observed. Therefore, it is expected that highly efficient use of the computing resources and software and highly significant research results will occur as a result of this proposal.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该提案的主要目标是利用 SDSC 的高性能计算 (HPC) 资源和计算流体动力学 (CFD) 软件来模拟人体呼吸道中的气流和气溶胶输送。有大量证据表明，暴露于环境中的颗粒物与人类健康有关。人们对生物战的认识不断提高，吸入式药物输送的使用越来越多，也强调需要更好地了解吸入气溶胶在人肺中的命运。过去，大多数关于人肺气溶胶输送的研究都集中在上呼吸道和大气道上。关于肺泡小气道的数据非常有限，并且对于那些现有的研究来说，存在严重的局限性，例如刚性壁、二维几何形状或无分叉的假设。我们在加州大学圣地亚哥分校的研究小组最近开发了具有顺应壁的三维、肺泡状和分叉气道的初步最先进模型。使用台式计算机进行的初始模拟产生了一些有趣且重要的结果。然而，台式计算机的计算能力严重限制了实际且非常重要的结果的有效产生。因此，我们建议利用SDSC的计算资源来帮助实现我们的研究目标。该提案的 PI 拥有三年多在另一个超级计算中心使用 CFD 软件（Fluent）和 HPC 资源的丰富知识，专注于当前的相关项目。在这个项目中，我们计划继续使用 Fluent 软件，该软件已经安装在 SDSC 计算机上，并且当前可以获得许可证。在之前使用该软件的经验中，已经观察到非常好的并行性能。因此，预计该提案将产生计算资源和软件的高效利用以及非常重要的研究成果。