CFD SIMULATION OF AIRFLOW AND AEROSOL TRANSPORT IN HUMAN ALVEOATED AIRWAYS

人体肺泡气道中气流和气溶胶输送的 CFD 模拟

• 批准号: 8171782
• 负责人: BAOSHUN MA
• 金额: $ 0.11万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171782
• 关键词: Aerosols; Arts; Awareness; Biological Warfare; Breathing; Computer Retrieval of Information on Scientific Projects Database; Computer software; Computers; Data; Drug Delivery Systems; Environment; Exposure to; Funding; Grant; Health; High Performance Computing; Human; Institution; Knowledge; Licensing; Link; Liquid substance; Lung; Particulate Matter; Performance; Production; Research; Research Personnel; Resources; Simulate; Source; Supercomputing; United States National Institutes of Health; computing resources; experience; interest; simulation; three-dimensional modeling

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this proposal is to use the high performance computing (HPC) resources and computational fluid dynamics (CFD) software at SDSC to simulate the airflow and aerosol transport in human airways. There have been extensive evidences linking the exposure to particulate matter in environment to human health. The increasingly awareness of biological warfare and the increasing use of inhalation drug delivery also emphasize the need to better understand the fate of inhaled aerosols in the human lung. In the past a majority of studies on aerosol transport in the human lung have focused on the upper and large airways. Data on alveolated small airways have been very limited, and for those existing studies there are serious limitations such as assumption of rigid wall, 2D geometry, or no bifurcation. Our research group at UCSD has recently developed preliminary state-of-the-art models of three-dimensional, alveolated, and bifurcated airways with compliant walls. Initial simulations using a desktop computer have produced some interesting and important results. However, the computing power of the desktop computer seriously limits the efficient production of realistic and highly significant results. Therefore, we propose to use the computing resources at SDSC to help realize our research objectives. The PI of this proposal has more than three years of extensive knowledge of using CFD software (Fluent) with HPC resources at another supercomputing center, focusing on a related project as the current one. In this project we plan to continue to use Fluent software, which was already installed on SDSC computers and licenses are currently available. In the previous experience with the software very good parallel performance has been observed. Therefore, it is expected that highly efficient use of the computing resources and software and highly significant research results will occur as a result of this proposal.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该提案的主要目的是使用SDSC的高性能计算（HPC）资源和计算流体动力学（CFD）软件来模拟人类气道中的气流和气溶胶传输。有广泛的证据将暴露于环境中的颗粒物与人类健康联系起来。越来越多的意识到生物战和吸入药物的越来越多的使用也强调需要更好地了解人类肺中吸入气溶胶的命运。过去，大多数关于人肺气溶胶运输的研究都集中在上部和大型气道上。关于肺泡的小气道的数据非常有限，对于那些现有的研究，存在严重的局限性，例如假设刚性壁，2D几何或没有分叉。我们在UCSD的研究小组最近开发了带有合规墙的三维，肺泡和分叉的航空公司的初步最先进模型。使用台式计算机的初始模拟产生了一些有趣且重要的结果。但是，台式计算机的计算能力严重限制了有效产生现实且高度重要的结果。因此，我们建议使用SDSC的计算资源来帮助实现我们的研究目标。该提案的PI在另一个超级计算中心使用HPC资源使用CFD软件（Fluent）有超过三年的广泛知识，重点介绍了一个相关项目作为当前的项目。在此项目中，我们计划继续使用流利的软件，该软件已经安装在SDSC计算机上，目前可用。在以前的软件经验中，已经观察到非常出色的并行性能。因此，预计该提案的高效使用计算资源和软件以及高度重要的研究结果将会发生。