STRUCTURAL MECHANISMS OF ION CHANNELS

离子通道的结构机制

• 批准号: 8170625
• 负责人: Stephen Barstow Long
• 金额: $ 0.37万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170625
• 关键词: Calcium; Cellular Membrane; Chloride Ion; Chlorides; Computer Retrieval of Information on Scientific Projects Database; Eukaryotic Cell; Funding; Genes; Grant; Human; Institution; Ion Channel; Ions; Laboratories; Measurement; Membrane Proteins; Metabolism; Neurons; Pharmacologic Substance; Potassium Channel; Process; Proteins; Research; Research Personnel; Resources; Running; Signal Transduction; Sodium; Source; Structure; United States National Institutes of Health; improved

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Membrane proteins of eukaryotic cells are crucial for a broad range of processes including metabolism, cellular signaling, and the relay of neuronal signals. While approximately one quarter of human genes encode membrane proteins and ~60% of clinically approved pharmaceuticals target them, our understanding of the mechanisms of these proteins is limited by a scarcity of three-dimensional information. My laboratory is focused on understanding the mechanisms of eukaryotic ion channels - membrane proteins that regulate the flow of ions across cellular membranes. While considerable progress has been made in understanding the mechanisms of potassium ion channels from crystal structures, we lack a detailed understanding of channels selective for other ions such as sodium, calcium, or chloride. We aim to determine the crystal structures of such channels and combine this structural information with functional measurements in order to better understand the mechanisms of channel function. In the long run, we hope that this information will be useful for improving human heath.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 真核细胞的膜蛋白对于包括代谢，细胞信号传导和神经元信号继电器在内的广泛过程至关重要。 虽然大约四分之一的人基因编码膜蛋白，约60％的临床认可的药物以它们为目标，但我们对这些蛋白质机制的理解受到三维信息的稀缺的限制。 我的实验室专注于理解真核离子通道的机理 - 调节离子跨细胞膜流动的膜蛋白。 尽管在了解晶体结构的钾离子通道的机制方面取得了长足的进步，但我们对选择其他离子（例如钠，钙或氯化物）的通道缺乏详细的理解。 我们旨在确定此类通道的晶体结构，并将这些结构信息与功能测量相结合，以更好地了解通道功能的机制。 从长远来看，我们希望此信息对改善人类荒地有用。