REGULATION OF MEMBRANE TRAFFICKING VIA PROTEIN-PROTEIN INTERACTIONS IN C ELEGAN

通过蛋白质-蛋白质相互作用调节线虫中的膜运输

• 批准号: 8171231
• 负责人: Anjon Audhya
• 金额: $ 0.24万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171231
• 关键词: Biological Models; Caenorhabditis elegans; Complex; Computer Retrieval of Information on Scientific Projects Database; Destinations; Funding; Grant; Institution; Membrane Protein Traffic; Organelles; Play; Proteins; RNA Interference; Regulation; Research; Research Personnel; Resources; Role; Source; Staging; Transmembrane Transport; United States National Institutes of Health; Work; interest; protein complex; protein protein interaction

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Understanding the mechanisms by which proteins and organelles are transported to their final destination has been fervently pursued for more than 40 years. Recently, several large protein complexes such as the exocyst and the HOPS complex have been found to play critical roles in the regulation of different stages of membrane transport. Using C. elegans as a model system, we are interested in exploring how other protein-protein interactions may influence additional components of membrane trafficking machinery. Roles for proteins identified using this approach can quickly be further explored using RNA interference, which has been shown to work exceptionally well in C. elegans

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 了解蛋白质和细胞器被运送到最终目的地的机制已被热烈追求40多年。最近，已经发现几种大型蛋白质复合物，例如外囊肿和啤酒花配合物在调节膜转运阶段的调节中起关键作用。使用秀丽隐杆线虫作为模型系统，我们有兴趣探索其他蛋白质 - 蛋白质相互作用如何影响膜运输机制的其他组成部分。使用RNA干扰可以快速探索使用这种方法鉴定的蛋白质的角色，该干扰已被证明在秀丽隐杆线虫中效果很好