XENOPUS LINKER PROTEINS

爪蟾连接蛋白

• 批准号: 8171406
• 负责人: Rebecca W Heald
• 金额: $ 0.24万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171406
• 关键词: Binding; Cells; Characteristics; Computer Retrieval of Information on Scientific Projects Database; Development; Elements; Funding; Grant; Institution; Link; Membrane; Mitosis; Movement; Organelles; Positioning Attribute; Process; Proteins; Proteomics; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Xenopus; base; egg; novel; tumor progression

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Membrane-bound organelles show a characteristic spatial organization and their regulated positioning and movement are key to fundamental processes like mitosis and cell polarization. Disruption of polarity and abnormal cellular organization are linked to the development and progression of cancer. Linker proteins between cytoskeletal elements and organelles are critical for determining cellular organization. We are using a Xenopus egg extract-based proteomics approach to identify novel potential linkers.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 膜结合细胞器表现出特有的空间组织，它们的调节定位和运动是有丝分裂和细胞极化等基本过程的关键。极性破坏和异常细胞组织与癌症的发生和进展有关。细胞骨架元件和细胞器之间的连接蛋白对于确定细胞组织至关重要。我们正在使用基于非洲爪蟾卵提取物的蛋白质组学方法来识别新的潜在接头。