IDENTIFICATION OF C05C89 INTERACTING PROTEINS

C05C89 相互作用蛋白的鉴定

• 批准号: 8171386
• 负责人: Karen F Oegema
• 金额: $ 0.24万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171386
• 关键词: Cell physiology; Centrioles; Centrosome; Cilia; Computer Retrieval of Information on Scientific Projects Database; Funding; Goals; Grant; Institution; Microtubule Stabilization; Organelles; Preparation; Proteins; Research; Research Personnel; Resources; Source; United States National Institutes of Health; interest; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Centrioles are small cylindrical organelles that are important in the stabilization of microtubules which perform several important cellular functions including centrosome assembly and cilia formation. Understanding how centrioles perform these different functions is of great interest. The goal of this project is to identify C05C8.9 interacting proteins. C05C8.9 is a novel centriolar protein that was identified in a TAP preparation of SAS-4 which is required for cilia formation.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 中心元素是小圆柱细胞器，在微管的稳定中很重要，这些微管执行几种重要的细胞功能，包括中心体组装和纤毛形成。 了解中心元如何执行这些不同的功能引起了极大的兴趣。该项目的目的是识别C05C8.9相互作用的蛋白质。 C05C8.9是一种新型的中心蛋白，在SAS-4的水龙头制备中被鉴定出来，这是纤毛形成所需的。