INCORPORATION OF SPIN-LABELED ORGANIC MOLECULES INTO CARBON NANOTUBES

将自旋标记有机分子掺入碳纳米管

• 批准号: 8172225
• 负责人: BORIS G DZIKOVSKI
• 金额: $ 0.86万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172225
• 关键词: Attention; Biodegradable microsphere; Blood Circulation; Blood Vessels; Cancerous; Carbon; Carbon Nanotubes; Computer Retrieval of Information on Scientific Projects Database; Drug Controls; Drug Delivery Systems; Electron Spin Resonance Spectroscopy; Electronics; Funding; Grant; Institution; Mechanics; Microscopy; Nanotechnology; Optics; Pharmaceutical Preparations; Publishing; Research; Research Personnel; Resolution; Resources; Science; Source; Spin Labels; Techniques; Tissues; United States National Institutes of Health; cancer therapy; design; electrical property; nanomaterials; nanoparticle; new technology; prospective; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Carbon nanotubes (CNT) are allotropes of carbon. They are extremely thin hollow cylinders made of carbon atoms. Unique mechanical and electrical properties of CNT make them potentially useful in many applications in nanotechnology, electronics, optics and other fields of material science. Recently, they have attracted attention as prospective drug delivery agents, especially in cancer treatment. Leaky blood vessels in tumors cause accumulation of nanoparticles introduced into the bloodstream in the cancerous tissue. Understanding incorporation of organic molecules in carbon nanotubes and delivery of the former can help in designing new drugs and treatment techniques. ACERT published a successful study on control drug release from micro-scale biodegradable microspheres. Studying drug release from nano-materials will be a further implementation of unique opportunities provided by ESR spectroscopy in general and novel technologies being developed in ACERT, such as high resolution ESR microscopy.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 碳纳米管（CNT）是碳的同素异形体。它们是由碳原子制成的非常薄的空心缸。 CNT的独特机械和电气性能使它们在纳米技术，电子，光学和其他材料科学领域的许多应用中可能有用。最近，它们吸引了作为前瞻性药物递送剂的关注，尤其是在癌症治疗中。肿瘤中的漏水血管导致引入癌组织中血液中的纳米颗粒的积累。了解有机分子在碳纳米管中的掺入和前者的递送可以帮助设计新药和治疗技术。 Acert发表了一项成功从微尺度可生物降解微球释放的对照药物释放的研究。从纳米材料中研究药物释放将是ESR光谱法在ACERT中开发的新型技术（例如高分辨率ESR显微镜）中提供的独特机会的进一步实施。