SD SIGNAL TRANSDUCTION CENTER

SD信号转导中心

• 批准号: 8168003
• 负责人: ANTHONY Martin GERDES
• 金额: $ 0.25万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168003
• 关键词: Cardiac Myocytes; Cell Death; Cells; Computer Retrieval of Information on Scientific Projects Database; Congestive Heart Failure; Detection; Funding; Goals; Grant; Heart; Heart failure; Institution; Lead; Maintenance; Malignant Neoplasms; Molecular; Pathway interactions; Physiological; Research; Research Personnel; Resources; Shapes; Signal Transduction; Source; Stress; United States National Institutes of Health; Work; cell growth; improved; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The lab will examine the pathways that regulate cell growth and differentiation, cell death, response to stress and the maintenance of constant physiological conditions. The goal is to understand the abnormalities that can occur in cells, which could lead to improved detection and treatment of a range of serious heart and cancer conditions. Chamber dilation in congestive heart failure is due to a maladaptive change in cardiac myocyte shape. Ongoing work is investigating the molecular signaling related to cellular remodeling in the progression of heart failure.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该实验室将研究调节细胞生长和分化、细胞死亡、应激反应以及维持恒定生理条件的途径。 目标是了解细胞中可能发生的异常，这可能会改善对一系列严重心脏病和癌症疾病的检测和治疗。 充血性心力衰竭中的心室扩张是由于心肌细胞形状的适应不良变化所致。 正在进行的工作正在研究心力衰竭进展中与细胞重塑相关的分子信号传导。