MT VET COBRE II CORE C: ANIMAL MODELS

MT VET COBRE II CORE C：动物模型

• 批准号: 8168414
• 负责人: David W Pascual
• 金额: $ 14.41万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168414
• 关键词: Animal Model; Animals; Arts; Autoimmune Diseases; Biological Factors; Brucella; Centers for Disease Control and Prevention (U.S.); Centers of Research Excellence; Certification; Communicable Diseases; Computer Retrieval of Information on Scientific Projects Database; Coxiella; Development; Disease; Equipment; Funding; Future; Goals; Grant; Institution; Investments; Laboratories; Laboratory Animal Production and Facilities; Leadership; National Center for Complementary and Alternative Medicine; Organism; Pathogenesis; Preparation; Protocols documentation; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Work; base; biodefense; biosafety level 3 facility; design; falls; member; methionylmethionine; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Animal Models Core (Core C) is directed by Dr. David Pascual and provides resources and expertise to meet the meet the needs of the COBRE II junior investigators and other investigators associated with the Center who propose to utilize animal models in their research and/or need expertise and advice in implementation of new animal models to enhance/expand their research programs. Core C is designed to (a) provide technical, methodological, and analytical support to Project Leaders and other Center investigators utilizing animal models of infectious disease pathogenesis, (b) provide resources and expertise to assist Center investigators in utilizing and/or developing new animal models to enhance or expand their research programs, and (c) facilitate access of Center investigators to the BSL-3 and ABSL-2 animal research facilities, assist in animal protocol preparation, and insure approvals are on file prior to any animal use. COBRE I to COBRE II Transition The development of Core C represents a natural transition from the COBRE I BSL-3 Core (Core D). During COBRE I, a BSL-3 Core was established to develop the necessary resources and facilities required for Center investigators in zoonotic disease research to undertake studies on BSL-3 organisms. The Center completed construction of a state-of-the-art BSL-3 facility during COBRE I. While COBRE funds were not used for the construction, the COBRE I BSL-3 Core provided resources for several key pieces of equipment to outfit the BSL-3 laboratories. The completion and CDC certification of this facility allowed us to move directly into BSL-3 aspects projects in Brucella and Coxiella pathogenesis that were funded through the NIH Rocky Mountain Research Center of Excellence in Biodefense. In addition, availability of this facility allowed us to successfully compete for an NIH Program Project from the National Center for Complementary and Alternative Medicine, which is a five year study of natural products' impact on reducing infectious and autoimmune diseases. Thus, a small investment of COBRE I resources resulted in funding of major program grants for Center investigators to work on BSL-3 diseases, which was an important goal of COBRE I. With completion of the goals of the current Core, the COBRE leadership and EAC considered the future direction this Core should take in COBRE II, and this was discussed extensively during the Fall 2008 EAC review. Based on input from COBRE II Project Leaders and the EAC members, we revised the scope of this Core creating the new Animal Models Core.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 动物模型核心（核心 C）由 David Pascual 博士指导，提供资源和专业知识，以满足 COBRE II 初级研究人员和与该中心相关的其他研究人员的需求，这些研究人员提议在其研究中使用动物模型和/或者需要专业知识和建议来实施新的动物模型，以加强/扩大他们的研究计划。核心 C 旨在 (a) 为项目负责人和利用传染病发病机制动物模型的其他中心研究人员提供技术、方法和分析支持，(b) 提供资源和专业知识以协助中心研究人员利用和/或开发新动物模型以增强或扩展其研究计划，(c) 方便中心研究人员进入 BSL-3 和 ABSL-2 动物研究设施，协助动物方案准备，并确保在任何动物使用之前获得批准存档。 COBRE I 到 COBRE II 的过渡 Core C 的开发代表了从 COBRE I BSL-3 Core（Core D）的自然过渡。在 COBRE I 期间，建立了 BSL-3 核心，以开发人畜共患疾病研究中心研究人员对 BSL-3 生物进行研究所需的必要资源和设施。该中心在 COBRE I 期间完成了最先进的 BSL-3 设施的建设。虽然 COBRE 资金没有用于建设，但 COBRE I BSL-3 核心为装备 BSL 的几个关键设备提供了资源-3个实验室。该设施的竣工和 CDC 认证使我们能够直接开展布鲁氏菌和柯克斯体发病机制的 BSL-3 方面项目，该项目由 NIH 落基山生物防御卓越研究中心资助。此外，该设施的可用性使我们能够成功竞争国家补充和替代医学中心的 NIH 计划项目，该项目是一项为期五年的研究，旨在研究天然产品对减少传染病和自身免疫性疾病的影响。因此，COBRE I 资源的小额投资为中心研究人员研究 BSL-3 疾病提供了主要计划拨款，这是 COBRE I 的一个重要目标。随着当前核心目标的完成，COBRE 领导层和EAC 考虑了该核心在 COBRE II 中应采取的未来方向，并在 2008 年秋季 EAC 审查期间对此进行了广泛讨论。根据 COBRE II 项目负责人和 EAC 成员的意见，我们修订了该核心的范围，创建了新的动物模型核心。