ADOLESCENT BARIATRICS ASSESSING HEALTH BENEFITS AND RISKS (TEEN-LABS U01 DK07249

青少年肥胖症评估健康益处和风险 (TEEN-LABS U01 DK07249

• 批准号: 8166721
• 负责人: MARY L BRANDT
• 金额: $ 1.37万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166721
• 关键词: Adolescence; Adolescent; Adult; Ancillary Study; Bariatrics; Benefits and Risks; Body Weight decreased; Characteristics; Comorbidity; Computer Retrieval of Information on Scientific Projects Database; Data Collection; Eating Behavior; Functional disorder; Funding; Future; Genetic; Goals; Grant; Health; Health Benefit; Impairment; Institution; Lead; Life; Liver; Medical; Morbid Obesity; National Institute of Diabetes and Digestive and Kidney Diseases; Obesity; Operative Surgical Procedures; Outcome; Plasma; Postoperative Period; Quality of life; Relative (related person); Research; Research Personnel; Research Project Grants; Resources; Risk; Safety; Source; Teenagers; Time; Tissues; United States National Institutes of Health; Whole Blood; Youth; age related; bariatric surgery; clinical decision-making; depressive symptoms; psychosocial

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To facilitate and accelerate research in Bariatric Surgery, the National Institute of Diabetes & Digestive, and Kidney Diseases (NIDDK) established the Longitudinal Assessment of Bariatric Surgery consortium (LABS). The LABS research project, as originally conceived, focused only on adult subjects undergoing bariatric surgery. However, an ancillary studies mechanism was also established to support other related research projects. Teen-LABS is one such related project. The primary goal of this observational Teen-LABS study is to collect baseline characteristics and postoperative outcomes of adolescents who are undergoing bariatric surgery in an effort to assess safety and efficacy of bariatric surgery. By mirroring LABS data collection, the Teen-LABS study will also allow us to estimate the relative merits of early surgery compared to delayed surgery for extremely obese youth. This comparison will lead to a better understanding of the plasticity of important medical and psychosocial obesity-related comorbidities. Moreover, this study will provide critical scientific information to inform clinical decision-making regarding appropriate timing of bariatric surgery. Severe obesity in adolescence is associated with medical and psychosocial impairments which may be more effectively treated with surgery during adolescence rather than later in adulthood. Specific Aim 1: To determine whether health significantly differs between adolescents and adults seeking bariatric surgery and thereby determine whether there are potential age-related health benefits in performing bariatric surgery earlier rather than later in the lifetime. Specific Aim 2: To identify early (30 day) and intermediate term (1-2 year) health risks for adolescents and adults undergoing bariatric surgery. Specific Aim 3: To document the psychosocial status of adolescents and adults with extreme obesity before bariatric surgery and 1 and 2 years after surgery. Psychosocial status will be examined in three major domains: depressive symptoms, eating behaviors, and quality of life. Specific Aim 4: To obtain and store biospecimens (serum, plasma, whole blood, and liver tissue) for research related to the aims of this study, and for future use by this consortium and ancillary studies for research into the pathophysiology and genetics of obesity and obesity related issues. Bariatric surgery is effective in treating extreme obesity in adults, and is most commonly used in the 5th decade of life. As more adolescents develop extreme obesity and seek bariatric surgery, our long term goal is to elucidate the health benefits and risks of surgical weight loss for adolescents. Our central hypothesis is that severe obesity in adolescence is associated with medical and psychosocial impairments which may be more effectively treated with surgery during adolescence rather than later in adulthood.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 为了促进和加速减肥手术的研究，美国国家糖尿病与消化研究所以及肾脏疾病（NIDDK）建立了减肥手术联盟（LABS）的纵向评估。最初构思的实验室研究项目仅着眼于接受减肥手术的成年受试者。但是，还建立了辅助研究机制，以支持其他相关研究项目。青少年lab是一个相关的项目。这项观察性青少年研究的主要目的是收集正在接受减肥手术的青少年的基线特征和术后结局，以评估减肥手术的安全性和功效。通过镜像实验室的数据收集，与极度肥胖的青年相比，与延迟手术相比，Teen-LABS研究还可以估算早期手术的相对优点。这种比较将使人们对重要的医学和社会心理肥胖相关合并症的可塑性有更好的了解。此外，这项研究将提供关键的科学信息，以告知有关适当的减肥手术时间的临床决策。 青春期严重的肥胖与医学和社会心理障碍有关，这些障碍可能会在青春期而不是成年后更有效地通过手术治疗。 具体目标1：确定青少年和寻求减肥手术的成年人之间的健康是否有显着不同，从而确定在早期进行减肥手术而不是一生中是否有潜在的与年龄相关的健康益处。 具体目标2：确定青少年和成年人接受减肥手术的早期（30天）和中期（1-2年）的健康风险。 特定目的3：记录青少年和成年人在减肥手术前的极端肥胖症以及手术后1和2年的心理社会心理状况。心理社会地位将在三个主要领域进行检查：抑郁症状，饮食行为和生活质量。 具体目的4：用于获得与本研究目的有关的研究，以获取和存储生物种子（血清，血浆，全血和肝组织），以及该财团和辅助研究的未来使用，用于研究肥胖和肥胖相关问题的病理生理学和遗传学。 减肥手术可有效治疗成年人的极端肥胖症，并且最常用于生命的第五个十年。随着越来越多的青少年发展极端肥胖并寻求减肥手术，我们的长期目标是阐明青少年的健康益处和手术减肥的风险。我们的中心假设是，青春期的严重肥胖与医学和社会心理障碍有关，这些障碍可能会在青春期而不是成年后更有效地通过手术治疗。