Prenatal Influences on Brain and Behavioral Development

产前对大脑和行为发育的影响

基本信息

批准号：
7454113
负责人：
SARAH J SHORT
金额：
$ 3.78万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-01-01 至 2008-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7454113
关键词：
Age Age-Months Age-Years Animals Antibody Formation Behavior assessment Behavioral Birth Weight Blood Circulation Brain Brain region Breeding Child Development Child health care Circadian Rhythms Classification Cognition Disorders Development Developmental Disabilities Disease Doctor of Philosophy Emotional Epidemiologic Studies Etiology Evaluation Exhibits Exposure to Feedback Fellowship Female Functional disorder Global Change Growth HPSE gene Hippocampus (Brain)Hormones Human Hydrocortisone Image Immune Immunity Individual Infant Infant Behavior Infant Development Infection Influenza Interferon Type II Interleukin-6 Invasive Laboratories Learning Disabilities Length Link Macaca mulatta Magnetic Resonance Imaging Measurement Measures Mental disorders Modeling Monkeys Mothers Names Neonatal Neopterin Neuronal Differentiation Neurosciences Neurosecretory Systems Nose Numbers Patient currently pregnant Peer Group Phase Physiologic pulse Physiology Positioning Attribute Postpartum Period Pregnancy Primates Psyche structure Psychopathology Pulse taking Reaction Research Resolution Risk Rodent Model Scanning Schizophrenia Sensory Process Social Behavior Staging Testing Time Training Ventricular Viral Virus Virus Diseases Virus Shedding Weaning Week behavior observation career cytokine design dexamethasone suppression test emotional reaction fetal flu hypothalamic-pituitary-adrenal axis in utero influenza virus strain interest neural circuit neurochemistry neuroimaging neuropsychiatry nonhuman primate postnatal pre-doctoral prenatal prenatal influence response size social group steroid hormone

项目摘要

DESCRIPTION (provided by applicant): The effects of maternal influenza exposure on the developing fetal brain and the associated risk for behavioral and hormone dysfunction will be examined. The importance of virus-induced changes in maternal immunity and placental physiology will be analyzed with respect to the development of the infant postpartum. The studies proposed for this fellowship are designed to: 1) create a nonhuman primate model of flu infection during pregnancy; 2) identify the physical, behavioral, and neuroendocrine profiles of flu-exposed and control infants; 3) measure hippocampal vulnerability to prenatal insult using structural MR imaging and assessment of the HPA axis in cortisol release and negative feedback. Development of a nonhuman primate model that utilizes a human derived strain of the influenza virus has important implications for understanding how flu exposure during pregnancy may impact the mental and physical health of children. Furthermore, these findings are relevant to neuropsychiatric diseases and cognitive disorders that may be due to disturbed prenatal development, involving high levels of maternal cytokines or steroid hormones that interrupt normal neuronal differentiation and development of the brain

描述（由申请人提供）：将检查母亲流感暴露对胎儿大脑发育的影响以及行为和激素功能障碍的相关风险。将根据婴儿产后发育来分析病毒引起的母体免疫力和胎盘生理学变化的重要性。该奖学金的研究旨在：1）创建怀孕期间流感感染的非人类灵长类动物模型； 2) 识别流感暴露婴儿和对照婴儿的身体、行为和神经内分泌特征； 3) 使用结构 MR 成像测量海马对产前损伤的脆弱性，并评估 HPA 轴的皮质醇释放和负反馈。利用人类衍生的流感病毒株开发非人类灵长类动物模型对于了解怀孕期间接触流感如何影响儿童的身心健康具有重要意义。此外，这些发现与神经精神疾病和认知障碍有关，这些疾病和认知障碍可能是由于产前发育障碍所致，涉及高水平的母体细胞因子或类固醇激素，会中断正常的神经元分化和大脑发育