Translational Research Evaluating Neurocognitive Memory Processes (TREC-MP)

评估神经认知记忆过程的转化研究 (TREC-MP)

• 批准号: 8097352
• 负责人: Shawn M McClintock
• 金额: $ 13万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8097352
• 关键词: Acute; Adverse effects; Affect; Amnesia; Animal Model; Anterograde Amnesia; Applications Grants; Appointment; Award; Basic Science; Cardiovascular Diseases; Clinical; Clinical Research; Clinical assessments; Cognitive; Cognitive Science; Complex; Depressed mood; Development; Development Plans; Disease; Disorientation; Electroconvulsive Shock; Electroconvulsive Therapy; Ensure; Etiology; Future; Goals; Herb; Human; Individual; Institutes; Intervention; K-Series Research Career Programs; Lead; Link; Major Depressive Disorder; Manuscripts; Measures; Medical center; Memory impairment; Mental Depression; Mentored Patient-Oriented Research Career Development Award; Mentors; Methodology; Methods; Mood Disorders; National Institute of Mental Health; Needs Assessment; Neurocognitive; Neuropsychology; New York; Outcome Measure; Participant; Pathway interactions; Patients; Pattern; Peer Review; Performance; Pharmacotherapy; Preceptorship; Primates; Process; Productivity; Property; Psychiatric therapeutic procedure; Psychometrics; Reaction Time; Recovery; Research; Research Personnel; Research Project Grants; Research Proposals; Resistance; Retrograde amnesia; Science; Scientist; Staging; Stimulus; Testing; Time; Translational Research; Universities; Work; career; career development; clinical application; clinically significant; cognitive function; cohort; comparative; computerized; design; effective therapy; experience; functional disability; functional outcomes; human subject; improved; innovation; magnetic seizure therapy; memory process; neurocognitive test; neuropsychological; nonhuman primate; novel; performance tests; prevent; public health relevance; research and development; research study; response; skills; sound; standard measure; statistics; theories; therapy design; therapy development

DESCRIPTION (provided by applicant): This proposal is for a K23 Mentored Patient Oriented Research Career Development Award that will prepare the candidate for a successful independent career in translational neurocognitive research. The candidate and his mentors at UT Southwestern Medical Center (UTSW) and Columbia University/New York State Psychiatric Institute (CU/NYSPI) designed a Staged Mentored and Arranged Transition (SMART) career development pathway to enable him to become a proficient, independent investigator working at the intersection of neurocognitive function, mood disorders, and neurostimulation interventions. This unique research niche will allow the candidate to leverage the expertise of his preceptors while establishing his individual identity as an independent investigator. The SMART pathway forms a collaborative network of expert mentors and advisors (Drs. Mustafa M. Husain, Sarah H. Lisanby, C. Munro Cullum, Herb Terrace, Ira Bernstein, George Alexopoulos, and Harold A. Pincus). The career development plan is comprised of scholarly didactics and seminars, expert preceptorship, hands-on experience at UTSW and CU/NYSPI, as well as tangible productivity including peer-reviewed manuscripts and grant applications. Unique to the candidate's career path is the pre- planned shift in primary appointment from UTSW to CU/NYSPI during this award period. This will facilitate his transitional goals as well as smooth his transition to independent status. The goal of his research project is to develop and conduct Translational Research Evaluating Neurocognitive Memory Processes (TREC-MP). The use of model animals to study neurocognitive functions has been employed extensively in basic science methodologies. However, the resulting applications for clinical human use have been limited. TREC-MP is a translational project that examines the psychometric properties in humans of experimental computerized neurocognitive measures developed for nonhuman primates undergoing electroconvulsive shock and magnetic seizure therapy. This incremental research study is designed to optimize the experimental neurocognitive battery in a healthy human cohort, then to determine the effects of depression on test performance, and finally to determine the neurocognitive performance of depressed subjects undergoing electroconvulsive therapy (ECT). The cognitive impact of ECT is well recognized and of considerable clinical significance, but what is less well understood is the complex interaction between depression and ECT on cognitive component processes. As such, newer methods of cognitive assessment are needed to elucidate similar and divergent cognitive processes across species, and identify underlying cognitive component processes of memory impairment in patients receiving ECT. As exemplified in recent NIMH translational neurocognitive research and clinical initiatives, one useful strategy would be the development of comparative nonhuman primate and human neurocognitive measures for specific neurocognitive domains and component processes. The application of a specific neurocognitive battery, predicated on basic science neurocognitive research with nonhuman primates provides a powerful method for understanding the cognitive component processes of memory deficits, thereby permitting the future development of targeted treatment interventions and useful clinical neurocognitive measures. [The aims of this project are: 1) Develop and validate experimental neurocognitive measures for use with healthy human participants, 2) Determine effects of depression on performance on experimental neurocognitive measures, and 3) Determine effects of ECT on performance on experimental neurocognitive measures.] Analyses will be conducted with both classical test and item response theory statistics. This project is scientifically innovative and important because it will provide a platform for the candidate to conduct translational neurocognitive research to help him understand the etiology of memory impairment and ultimately design appropriate clinical neurocognitive measures and interventions. The candidate's SMART pathway and TREC-MP project set the stage for his individualized and systematic development as an independent translational neurocognitive scientist. PUBLIC HEALTH RELEVANCE: Impaired cognitive functions associated with psychiatric treatments of severe depression contribute to poor functional outcomes. The objective of this career development award is for the candidate to become a proficient translational neurocognitive scientist. The long-term goal is for this translational neurocognitive research to provide a clearer understanding of the cognitive component processes that underscore cognitive functional impairments in order to develop psychometrically sound neurocognitive outcome measures and targeted treatment interventions.

描述（由申请人提供）：该建议是针对K23指导的以患者为导向的研究职业发展奖，该奖项将为候选人做好转化神经认知研究的成功独立职业的准备。候选人及其导师在UT西南医学中心（UTSW）和哥伦比亚大学/纽约州精神病学研究所（CU/NYSPI）设计了一项阶级的指导和安排过渡（SMART）职业发展途径，使他成为一名在神经认知功能的介入中，使他成为一名熟练，独立的研究人员，并使其成为神经认知功能，情绪分离，Moot disororders and Neuerolostimutions和Neurostimutions和Neuerostimutions和Neuerostimutions Interventions和Neuerostimutions和Neuerostimutions Interventions。这项独特的研究利基市场将使候选人能够在建立自己的独立调查员身份的同时利用他的主持人的专业知识。智能途径构成了专家导师和顾问的合作网络（Mustafa M. Husain博士，Sarah H. Lisanby，C。MunroCullum，Herb Terrace，Ira Bernstein，George Alexopopoulos和Harold A. Pins）。职业发展计划由学术教学和研讨会，专家录取，UTSW和CU/NYSPI的实践经验以及有形的生产力，包括同行评审的手稿和赠款应用程序。候选人的职业道路独有的是在此奖项期间从UTSW到CU/NYSPI的主要任命的预计划转变。这将促进他的过渡目标，并顺利过渡到独立地位。他的研究项目的目的是开发和进行评估神经认知记忆过程（TREC-MP）的转化研究。使用模型动物来研究神经认知功能已广泛用于基础科学方法。但是，临床人使用的结果应用受到限制。 TREC-MP是一个转化项目，该项目研究了针对接受电击性休克和磁性癫痫发作疗法的非人类灵长类动物开发的实验计算机神经认知措施的心理测量特性。这项增量研究旨在优化健康人群中的实验性神经认知电池，然后确定抑郁症对测试性能的影响，最后确定接受电击疗法（ECT）的抑郁受试者的神经认知性能。 ECT的认知影响是广泛的，具有相当大的临床意义，但知之甚少的是抑郁症与ECT在认知成分过程中的复杂相互作用。因此，需要更新的认知评估方法来阐明物种之间的相似和不同的认知过程，并确定接受ECT患者的记忆障碍的潜在认知成分过程。正如最近的NIMH转化神经认知研究和临床计划中所说的那样，一种有用的策略是开发针对特定神经认知领域和成分过程的比较非人类灵长类动物和人类神经认知度量。基于非人类灵长类动物的基础科学神经认知研究的特定神经认知电池的应用为理解记忆缺陷的认知成分过程提供了一种有力的方法，从而使未来的有针对性的治疗干预措施和有用的临床神经认知指标的未来发展。 [该项目的目的是：1）开发和验证实验性神经认知方法与健康的人参与者一起使用，2）确定抑郁症对性能对实验神经认知措施的影响，3）确定ECT对实验神经认知措施的影响。该项目在科学上具有创新性和重要性，因为它将为候选人提供一个平台进行转化神经认知研究，以帮助他了解记忆障碍的病因，并最终设计适当的临床神经认知措施和干预措施。候选人的智能途径和TREC-MP项目为他作为独立的转化神经认知科学家的个性化和系统发展奠定了基础。 公共卫生相关性：与严重抑郁症的精神治疗相关的认知功能受损，导致功能不良。这个职业发展奖的目的是使候选人成为一名熟练的翻译神经认知科学家。长期目标是这项翻译神经认知研究，以更清楚地了解认知成分过程，这些过程强调了认知功能障碍，以制定精神上声音的神经认知结果指标和靶向治疗干预措施。