Tissue Based Small Animal Model for HIV Drug Discovery

用于 HIV 药物发现的基于组织的小动物模型

• 批准号: 8233177
• 负责人: CRAIG FRANKLIN
• 金额: $ 167.02万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-06 至 2011-12-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8233177
• 关键词: Advanced Development; Animal Model; Contracts; Development; Disease; Engineering; HIV; HIV-1; Immunodeficient Mouse; Liquid substance; Modeling; Molecular; National Institute of Allergy and Infectious Disease; Quality Control; Sampling; Therapeutic; Tissue Donors; Tissues; Viral; Virus; animal tissue; base; drug discovery; in vitro Model; in vivo; novel; pre-clinical; reconstitution; research clinical testing

The objective of this contract is to further the preclinical development of novel therapies (low molecular weigh organic molecules, biologics, and engineered viruses) for HIV- 1 through pre-clinical testing in the well characterized SCID-hu Thy/Liv modle small animal model. The major scientific functions of this contract are listed below: 1. Evaluate HIV therapeutics in an in vitro model 2. Evaluate potential HIV-1 therapeutics in vivo in a validated small-animal model 3. Maintain quality control/assurance of viral stocks, donor tissue, and reconstituted immunodeficient mice 4. Further characterize or develop the animal model and adapt newly discovered models 5. Collect samples of animal tissues and/or fluids and prepare such samples for shipment

该合同的目的是通过在表征良好的SCID/LIV THY/LIV MODLE小动物模型中通过临床前测试来进一步为HIV-1的新疗法（低分子量有机分子，生物制剂和工程病毒）的临床前开发。 本合同的主要科学功能如下： 1。评估体外模型中的HIV治疗方法 2。在经过验证的小动物模型中评估体内潜在的HIV-1治疗剂 3。维持病毒量，供体组织和重组的免疫缺陷小鼠的质量控制/保证 4。进一步表征或发展动物模型并适应新发现的模型 5。收集动物组织和/或液体的样品，并准备此类样品以进行运输