PRICE: Pivotal Research in Cardiology in the Elderly

PRICE：老年人心脏病学的关键研究

基本信息

批准号：
7390756
负责人：
MICHAEL W RICH
金额：
$ 5.59万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-04-01 至 2009-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7390756
关键词：
Accounting Address African American Age Age-Years Aging Aortic Valve Stenosis Area Atrial Fibrillation Award Basic Science Behavior Cardiology Cardiovascular Diseases Cardiovascular system Caring Cause of Death Cessation of life Clinical Clinical Investigator Clinical Research Clinical Trials Complex Condition Coupled Development Diagnosis Disease Elderly Electronics Electrophysiology (science)Epidemiology Exhibits Exposure to Fostering Frail Elderly Functional disorder Future General Population Genetic Geriatrics Health Services Heart Valve Diseases Heart failure High Prevalence Hispanic Americans International Investigation Knowledge Light Methodology Minority Groups Mitral Valve Insufficiency Molecular Biology Molecular and Cellular Biology Morbidity - disease rate Not Hispanic or Latino Numbers Outcome Pattern Persons Population Prevention Prevention strategy Preventive Printing Proceedings and Conferences Proceedings, Conference Public Health Publications Qualifying Range Rate Recommendation Request for Proposals Research Research Activity Research Design Research Personnel Scientist Series Sinus Smoking Source State-of-the-Art Reviews Structure Syndrome Travel United States Woman acute coronary syndrome age effect age related attributable mortality base cardiovascular risk factor career day design disability expectation heart rhythm improved interdisciplinary collaboration interest knowledge base member men middle age mortality older men programs size symposium

项目摘要

DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) is the leading cause of death and major disability in older adults, and approximately 85% of all cardiovascular deaths in the U.S. occur in persons over 65 years of age. Moreover, although major advances over the past 30 years have led to greatly enhanced understanding of cardiovascular diseases in the elderly, critically important questions remain unanswered. The Pivotal Research in Cardiovascular Syndromes in the Elderly (PRICE) conference series was conceived in 1999 as a mechanism to concisely review state-of-the-art knowledge, identify critical gaps in that knowledge, and define a prioritized agenda for cardiovascular aging research in the ensuing 5-10 years. PRICE-1 (1999) provided an overview of major topics, with the expectation that subsequent PRICE symposia would explore specific topics in greater detail. Accordingly, PRICE-2 (2002) focused on acute coronary syndromes in the elderly, and the present proposal requests support for PRICE-3 (2004), PRICE-4 (2006), and PRICE-5 (2008), which will address heart failure, electrophysiology and rhythm disorders, and preventive cardiology, respectively. Specific aims for each PRICE conference include: 1. convene an international cadre of distinguished scientists and clinical investigators to define the current knowledge base and identify key gaps in knowledge that should serve as targets for future research; 2. foster interdisciplinary collaborations to enhance understanding of the complex interactions between aging and CVD; 3. stimulate career interests and development of promising young investigators; and 4. widely disseminate the conference's findings, including a broad-based but prioritized research agenda in each of the major topic areas. These objectives will be accomplished through a structured series of presentations and discussions addressing key topics ranging from molecular biology and genetics to epidemiology, clinical trials, and geriatrics. A Young Investigator Travel Award Program will provide support for attendance by qualified young investigators, and specific efforts will be made to engage women and minority group members at all levels of participation. Significance. CVD is an enormous public health problem in the U.S., and the magnitude of this problem is likely to increase exponentially as the population ages over the next several decades. It is therefore essential to accelerate the pace of research in cardiovascular aging and CVD in the elderly, and the PRICE series of conferences will provide specific recommendations regarding potentially fruitful avenues of investigation that are likely to have the greatest impact in advancing understanding of the fundamental mechanisms responsible for cardiovascular aging and in improving clinical care and outcomes for older adults with CVD.

描述（由申请人提供）：心血管疾病 (CVD) 是老年人死亡和重大残疾的主要原因，在美国，约 85% 的心血管死亡发生在 65 岁以上的人群中。此外，尽管过去 30 年的重大进展极大地提高了对老年人心血管疾病的认识，但至关重要的问题仍未得到解答。老年人心血管综合征关键研究 (PRICE) 系列会议于 1999 年构想为一种机制，旨在简明回顾最新知识、确定知识中的关键差距，并确定老年人心血管衰老研究的优先议程。接下来的5-10年。 PRICE-1（1999）提供了主要主题的概述，并期望随后的 PRICE 研讨会将更详细地探讨特定主题。因此，PRICE-2 (2002) 重点关注老年人的急性冠状动脉综合征，目前的提案请求支持 PRICE-3 (2004)、PRICE-4 (2006) 和 PRICE-5 (2008)，这将解决心脏问题分别是衰竭、电生理学和心律失常以及预防心脏病学。每次 PRICE 会议的具体目标包括： 1. 召集一支由杰出科学家和临床研究人员组成的国际骨干队伍，确定当前的知识库并确定知识中的关键差距，以作为未来研究的目标； 2. 促进跨学科合作，以加深对衰老与CVD之间复杂相互作用的理解； 3.激发有前途的年轻研究者的职业兴趣和发展； 4. 广泛传播会议成果，包括每个主要主题领域基础广泛但优先的研究议程。这些目标将通过一系列结构化的演讲和讨论来实现，这些演讲和讨论涉及从分子生物学和遗传学到流行病学、临床试验和老年病学等关键主题。青年研究员旅行奖励计划将为合格的年轻研究员参加提供支持，并将做出具体努力，让妇女和少数群体成员参与各级活动。意义。心血管疾病在美国是一个巨大的公共卫生问题，随着未来几十年人口老龄化，这一问题的严重程度可能呈指数级增长。因此，加快老年人心血管衰老和心血管疾病的研究步伐至关重要，PRICE 系列会议将就可能富有成效的研究途径提供具体建议，这些研究途径可能对增进对基本机制的理解产生最大的影响负责心血管衰老以及改善患有心血管疾病的老年人的临床护理和结果。