Oral Screening in India using Optical Imaging Technology

印度使用光学成像技术进行口腔筛查

基本信息

批准号：
7463924
负责人：
Ann M Gillenwater
金额：
$ 5.92万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-01 至 2010-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7463924
关键词：
Algorithms Aneuploidy Appearance Appendix Area Benign Biological Biological Markers Biopsy Breast Cancer Center Cancer Detection Cancer Etiology Cancer Patient Cancerous Carcinoma Categories Cessation of life Clinical Collaborations Collagen Communities Country Cytology Data Depth Detection Developed Countries Developing Countries Development Devices Diagnosis Diagnostic Disease Dysplasia Early Diagnosis Early Intervention Electronics Enrollment Environment Epithelial Epithelium Evaluation Excision Faculty Fiber Optics Fluorescence Funding Genetic Gold Head and Neck Surgery Health Hemoglobin Histologic Histology Histopathology Hospitals Human Hyperkeratosis Image Imaging technology India Individual Inflammation Inflammatory Institutes International Intervention Invasive Investigation Keratin Lateral Lead Lesion Leukoplakia Life Light Lighting Localized Loss of Heterozygosity Malignant - descriptor Malignant Neoplasms Malignant neoplasm of prostate Measurement Measures Medical Methodology Microscope Microscopic Mitochondria Molecular Molecular Abnormality Mouth Carcinoma Mouth Neoplasms Mucous Membrane Neoplasms Non-Invasive Cancer Detection Optics Oral Oral Diagnosis Oral Tobacco Oral cavity Oral mucous membrane structure Organ Outcome Oxidation-Reduction Patients Pattern Peripheral Persons Physicians Pilot Projects Population Predictive Value Premalignant Property Recruitment Activity Relative (related person)Research Project Grants Resolution Resources Risk Sampling Scientist Screening for Oral Cancer Screening for cancer Screening procedure Sensitivity and Specificity Signal Transduction Site Smoke Source Southeastern Asia Spectrum Analysis Staging Standards of Weights and Measures Survival Rate System Techniques Technology Testing Texas Time Tissues Tobacco Tobacco Use Cessation United States United States National Institutes of Health Variant Videoconferences Videoconferencing Visit Woman Work absorption base cancer diagnosis carcinogenesis chromophore clinical Diagnosis computerized data processing cost detector digital experience functional outcomes human subject improved malignant mouth neoplasm mathematical model member men mortality mouth squamous cell carcinoma neoplastic new technology optical imaging oral dysplasia oral lesion oral surgery specialty oral tissue prospective size tool transmission process tumor volunteer

项目摘要

DESCRIPTION (provided by applicant): Oral cancer is the sixth most common cancer worldwide and over two thirds of cases occur in developing countries. In India, it is the most common cancer in men and the third most common in women. Only half of oral cancer patients live 5 years, even less of those with advanced stage disease survive. Advances in early detection and diagnosis would greatly improve survival and decrease suffering from oral cancer. Optical based diagnostic aids are promising new technologies to improve detection of epithelial malignancies. During carcinogenesis, the optical properties of tissue are altered and these changes can be used to non-invasively distinguish normal from neoplastic mucosa. The objective of this international collaborative project, which builds upon previous NIH funded work, is to determine whether new optical imaging technology, fluorescence and reflectance imaging and spectroscopy, can facilitate early detection and diagnosis of oral neoplasia in a high risk population in India. Our first Aim is to determine whether multispectral imaging and spectroscopy can improve screening and diagnosis of potentially malignant oral lesions in a high risk population in India. We will obtain wide-field autofluorescence and reflectance images of oral premalignant lesions (OPLs) in 90 patients who are recruited for oral cancer screening trials at the Tata Memorial Hospital in Mumbai India. These images will be compared to findings using standard white light (WL) illumination. At the same time, an in depth, focal interrogation from several sites using fluorescence and reflectance spectra will be performed. Clinical diagnoses using standard white light, clinical diagnoses using multispectral imaging, spectroscopy data, and cytology and histopathology diagnoses will be compared to determine the positive and negative predictive value of using the device. In Aim 2, we will determine whether this technology can improve screening and diagnosis in an Indian population with high risk for oral cancer but no clinically visible lesions using similar methodology. In Aim 3, we evaluate the correlation of presence of genetic damage (such as aneuploidy and loss of heterozygosity) and morphologic changes (hyperkeratosis, inflammation, dysplasia) to altered optical signatures. Successful completion of this project will determine the diagnostic potential and applicability of this technology for oral cancer detection and diagnosis in communities with limited resources. 7. Project Narrative Oral cancer is the sixth most common cancer worldwide and over two thirds of cases occur in developing countries. In India, it is the most common cancer in men and the third most common in women. Only half of oral cancer patients live 5 years, even less of those with advanced stage disease survive. Advances in early detection and diagnosis would greatly improve survival and decrease suffering from oral cancer. Optical based diagnostic aids are promising new technologies to improve detection of epithelial malignancies. The objective of this international collaborative project, which builds upon previous NIH funded work, is to determine whether new optical imaging technology, fluorescence and reflectance imaging and spectroscopy, can facilitate early detection and diagnosis of oral neoplasia in a high risk population in India. We will determine whether multispectral imaging and spectroscopy can improve screening and diagnosis of potentially malignant oral lesions in a high risk population in India. We will compare optical data in 190 subjects who are recruited for oral cancer screening trials at the Tata Memorial Hospital in Mumbai India, to standard clinical diagnosis, histopathologic results, and molecular biomarker findings. Successful completion of this project will determine the diagnostic potential and applicability of this multispectral imaging and spectrsocpy technology for oral cancer detection and diagnosis in communities with limited resources.

描述（由申请人提供）：口腔癌是全球第六大常见癌症，超过三分之二的病例发生在发展中国家。在印度，它是男性中最常见的癌症，也是女性中第三常见的癌症。只有一半的口腔癌患者能活 5 年，晚期疾病患者的生存期更少。早期检测和诊断的进步将大大提高生存率并减少口腔癌的患病率。基于光学的诊断辅助设备是改善上皮恶性肿瘤检测的有前途的新技术。在癌变过程中，组织的光学特性发生改变，这些变化可用于非侵入性地区分正常粘膜和肿瘤粘膜。该国际合作项目以 NIH 先前资助的工作为基础，其目标是确定新的光学成像技术、荧光和反射成像和光谱学是否可以促进印度高危人群口腔肿瘤的早期检测和诊断。我们的第一个目标是确定多光谱成像和光谱学是否可以改善印度高危人群中潜在恶性口腔病变的筛查和诊断。我们将获得 90 名患者的口腔癌前病变 (OPL) 的宽视场自发荧光和反射图像，这些患者被招募到印度孟买塔塔纪念医院进行口腔癌筛查试验。这些图像将与使用标准白光 (WL) 照明的结果进行比较。同时，将使用荧光和反射光谱从多个地点进行深入、集中的询问。将比较使用标准白光的临床诊断、使用多光谱成像、光谱数据的临床诊断以及细胞学和组织病理学诊断，以确定使用该设备的阳性和阴性预测值。在目标 2 中，我们将确定该技术是否可以使用类似的方法改善口腔癌高风险但没有临床可见病变的印度人群的筛查和诊断。在目标 3 中，我们评估了遗传损伤（例如非整倍性和杂合性丧失）和形态变化（角化过度、炎症、发育不良）与光学特征改变的相关性。该项目的成功完成将确定该技术在资源有限的社区中用于口腔癌检测和诊断的诊断潜力和适用性。 7. 项目叙述口腔癌是全球第六大常见癌症，超过三分之二的病例发生在发展中国家。在印度，它是男性最常见的癌症，也是女性第三常见的癌症。只有一半的口腔癌患者能活 5 年，晚期疾病患者的生存期更少。早期检测和诊断的进步将大大提高生存率并减少口腔癌的患病率。基于光学的诊断辅助设备是有前途的新技术，可以改善上皮恶性肿瘤的检测。该国际合作项目以 NIH 先前资助的工作为基础，其目标是确定新的光学成像技术、荧光和反射成像和光谱学是否可以促进印度高危人群口腔肿瘤的早期检测和诊断。我们将确定多光谱成像和光谱学是否可以改善印度高危人群潜在恶性口腔病变的筛查和诊断。我们将把在印度孟买塔塔纪念医院招募进行口腔癌筛查试验的 190 名受试者的光学数据与标准临床诊断、组织病理学结果和分子生物标志物发现进行比较。该项目的成功完成将确定这种多光谱成像和光谱扫描技术在资源有限的社区中用于口腔癌检测和诊断的诊断潜力和适用性。