Evolution and Human Reproduction: A longitudinal study of the Dogon of Mali

进化与人类繁殖：马里多贡人的纵向研究

• 批准号: 8119714
• 负责人: Beverly Ilse Strassmann
• 金额: $ 4.99万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-04 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8119714
• 关键词: Address; Adolescence; Amenorrhea; Anthropology; Behavior; Biological; Biology; Blood Pressure; Books; Censuses; Child; Child Mortality; Contraceptive Agents; Contraceptive methods; Data; Data Set; Developing Countries; Development; Disease; Epidemiology; Evolution; Female; Fertility; Genetic; Growth; Growth and Development function; Gynecology; Hazard Models; Health; Hormones; Human; Infant; Infertility; Lead; Link; Logistic Regressions; Longevity; Longitudinal Studies; Mali; Medicine; Menopause; Menstrual cycle; Menstruation; Metabolic Diseases; Mothers; Natural Fertility; Parents; Pattern; Phenotype; Physicians; Population; Public Health; Reproduction; Reproductive Medicine; Risk; Rural; Sample Size; Sampling; Science; Scientist; Sexuality; Signal Transduction; Somatotropin; Statistical Methods; Time; United States; Variant; Woman; Work; design; experience; family structure; father role; grandparent; infancy; life history; male; malignant breast neoplasm; mortality; offspring; peer; population health; pregnant; reproductive; reproductive function; reproductive success

DESCRIPTION (provided by applicant): The proposed scholarly work is a book to be titled: Evolution and Human Reproduction: A longitudinal study in the Dogon of Mali. It draws on over 20 years of quantitative data that the author collected in nine rural villages (population 5000) situated along the Bandiagara Escarpment. The Dogon are a natural fertility population which means that their reproductive patterns are not confounded by contraception. Hence they are ideal for studying the evolved mechanisms that underlie reproduction and behavior. The book will address such questions as: What causes variation in female fertility and child mortality? Are life history trade-offs observable in the data? What are the developmental origins of metabolic disease? How many lifetime menses do women experience if they spend most of the time pregnant or in lactational amenorrhea? In such women is the risk for breast cancer lower? Why did menopause evolve and what effect do grandparents have on children's growth and survival? What is the function of menstrual huts? Do women synchronize their menstrual cycles? The book is distinguished from its peers primarily by the availability of the author's unique, longitudinal data sets on fertility, mortality, menstruation, health, hormones, growth, and genetics. Sample sizes are large. For example, the study of menstruation includes data from a census of women present at the menstrual huts on each of 736 consecutive nights, including 550 menstrual onsets. The study of child growth, development, and survival includes 1700 children, most of whom were followed from infancy to late adolescence. The data on grandparents has a sample size of 6800 grandparents. State of the art statistical methods, such as logistic regression, Cox regression, and hazards modeling, were used in the analyses. The target audience is physicians and scientists.

描述（由申请人提供）： 拟议的学术工作是一本书，标题为：进化和人类繁殖：马里多登的纵向研究。它借鉴了作者在Bandiagara悬崖上收集的九个农村村庄（人口5000）收集的20多年的定量数据。多贡是天然的生育率，这意味着它们的生殖模式不会因避孕而混淆。因此，它们非常适合研究基于繁殖和行为的进化机制。该书将解决以下问题：是什么原因导致女性生育和儿童死亡的变化？生活历史历史记录在数据中是否可以观察到？代谢疾病的发育起源是什么？如果女性大部分时间在怀孕或泌乳闭经中，女性会经历多少终身月经？在这样的女性中，乳腺癌的风险降低了吗？为什么更年期会进化？祖父母对儿童的成长和生存产生什么影响？月经小屋的功能是什么？女人会同步月经周期吗？这本书与同龄人的区别主要是由作者独特的，纵向数据集的生育，死亡，月经，健康，荷尔蒙，生长和遗传学的可用性。样本量很大。例如，对月经的研究包括连续736个晚上的月经小屋中出现的女性普查数据，包括550个月经。对儿童成长，发育和生存的研究包括1700名儿童，其中大多数是从婴儿期到青春期晚期的。关于祖父母的数据的样本量为6800个祖父母。分析中使用了最先进的统计方法，例如逻辑回归，COX回归和危害建模。目标受众是医生和科学家。