Admin. Core Interdepartmental Two-photon Imaging Center

行政。

基本信息

批准号：
7408917
负责人：
DALTON JAMES SURMEIER
金额：
$ 30.23万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-12-01 至 2011-11-30
项目状态：
已结题

项目摘要

The administration of the Center Core will be distributed into three parts: Administrative Core, Imaging Cores, and a Steering Committee. The Administrative Core will be managed by a Core Advisor who will be assisted by an administrative staff (see Chart on next page). The Core Advisor (22% effort) will be in charge of equipment purchases and negotiating prices with vendors (especially where multiple purchases may enable price reductions), managing the administrative staff, maintaining an inventory of core equipment and supplies, scheduling regular meetings of the Steering Committee, and serving as liaison between the Steering Committee and the Core Directors. He will also be responsible for overseeing the system improvement projects, coordinating activities with our corporate partner and consultants, and organizing and completing the annual reports to NIH. Dr. Hockberger, Director of the 2P Imaging Cores in Physiology and consultant on the 2P cores in Pediatrics and Neurology, has agreed to serve as the Core Advisor. He has been active in the field of optical physiology for 25 years, and he has made seminal contributions related to dendritic Ca2+ signaling, the role of differential adhesion in neuronal migration and pathfinding, and the sources and remedies of phototoxicity during live cell microscopy. He has been responsible for developing imaging resources (including CCD-based and 2P imaging) at NU, Loyola University (Chicago), University of Erlangen (Germany), and the University of Bonn (Germany). He has been an active participant in the International Society for Optical Engineers (SPIE) for the past 12 yrs, and he has been an invited speaker at numerous national and international symposia. At NU, he has taken a leading role in the education of graduate students and postdocs on the quantitative aspects of biological imaging. Since 1992, he has directed a graduate course (IGP 415: Biological Imaging: Principles and Applications) that teaches the theory and practice of quantitative image analysis in the life sciences. Each imaging core will be managed by a Core Director. We have identified appropriate faculty who have agreed to serve as Core Directors (see Chart), and their effort (5%) will be contributed by their respective departments. Directors will be responsible for oversight of the core, advising users on policies within the core, and keeping track of core usage. Each Director will have technical support to assist in running the day to day activities of the core (see Technical support, below). Oversight of the Center Core will be the responsibility of a Steering Committee comprised of the PI, senior faculty representing the various departments involved in this proposal, and the Core Advisor (ex officio). Dr. Surmeier (PI) has been the driving force behind the creation of the 2P imaging cores in

中心核心的管理将分为三个部分：行政核心、影像核心和指导委员会。行政核心将由一名核心顾问管理，他将由行政人员协助（见下页图表）。核心顾问（22％的努力）将负责设备采购以及与供应商谈判价格（特别是在多次采购可能使降价）、管理行政人员、维护核心设备库存以及供应，安排指导委员会的定期会议，并充当指导委员会之间的联络人委员会和核心董事。他还将负责监督系统改进项目，与我们的企业合作伙伴和顾问协调活动，并组织和完成向 NIH 提交年度报告。 Hockberger 博士，生理学 2P 成像核心主任兼儿科 2P 核心顾问和神经病学，已同意担任核心顾问。他一直活跃在光学生理学领域 25 年来，他在树突状 Ca2+ 信号传导、微分的作用等方面做出了开创性贡献。神经元迁移和寻路过程中的粘附，以及活体过程中光毒性的来源和补救措施细胞显微镜检查。负责开发影像资源（包括基于CCD和2P 成像），在国立大学、洛约拉大学（芝加哥）、埃尔兰根大学（德国）和波恩大学（德国）。他是国际光学工程师学会（SPIE）的积极参与者在过去的12年里，他多次受邀在国内和国际研讨会上发表演讲。在NU，他在研究生和博士后的定量方面的教育中发挥了主导作用生物成像。自 1992 年以来，他指导了研究生课程（IGP 415：生物成像：原理和应用）教授生命科学中定量图像分析的理论和实践。每个成像核心将由核心总监管理。我们已经确定了合适的教师同意担任核心董事（见图表），他们的努力（5%）将由各自部门贡献。董事将负责监督核心，就核心内的政策向用户提供建议，并跟踪核心使用情况。每位董事都将获得技术支持，以协助日常运营核心活动（请参阅下面的技术支持）。中心核心的监督将由 PI 组成的指导委员会负责，代表参与本提案的各个部门的高级教师以及核心顾问（当然）。 Surmeier 博士（PI）一直是 2P 成像核心创建背后的驱动力