In-Vivo Electrophysiology Imaging

体内电生理学成像

• 批准号: 8109309
• 负责人: Barry London
• 金额: $ 74.99万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8109309
• 关键词: Adrenergic Agents; Animal Model; Arrhythmia; Autologous; Award; Cardiac Surgery procedures; Cardiovascular system; Caring; Clinical; Defibrillators; EFRAC; Electrophysiology (science); Funding; Heart; Heart Diseases; Human; Image; Imaging Techniques; Implant; Infarction; Ischemia; Morbidity - disease rate; Patients; Risk; Stem cells; Stratification; Sudden Death; System; Techniques; Therapeutic Intervention; Time; Two-Dimensional Doppler Echocardiography; United States; Virus; abstracting; adrenergic; effective therapy; high risk; improved; in vitro testing; in vivo; mortality; novel; tool

Abstract Arrhythmias are a major cause of morbidity and mortality, with more than 250,000 people dying suddenly each year in the United States. Most arrhythmias are acquired and result from damage to the heart or its electrical system by ischemia, infarction, cardiac surgery, viruses, and assorted non- cardiac diseases. Our ability to identify which patients are at the highest risk of sudden death is poor, with ejection fraction being the only major clinical tool available for risk stratification. In addition, internal cardioverter-defibrillator (ICD) placement is the only effective therapy for high risk patients. Thus, the identification for novel tools to study arrhythmias in-vivo and stratify arrhythmic risk would represent a major advance to cardiovascular care. With the funding from the Pioneer Award, we will develop two novel and revolutionary techniques to image electrical activity in the intact heart in-vivo. First, we will adapt the most common clinical imaging technique, two-dimensional doppler echocardiography, to detect electrical activity in real time. Second, we will develop a modified autologous stem cell implant to detect adrenergic activity in the heart. These techniques will be developed in-vitro, tested in-vivo using animal models, and applied to humans when possible. If successful, both techniques will increase our understanding of arrhythmia mechanisms, improve risk stratification in patients at risk for sudden death, and guide therapeutic interventions.

抽象的 心律不齐是发病率和死亡率的主要原因，有25万人死亡 每年在美国突然。大多数心律不齐是获得的，并因损害而造成 缺血，梗塞，心脏手术，病毒和各种非 - 的心脏或其电气系统 心脏病。我们确定哪些患者处于猝死风险最高的能力很差， 射血分数是唯一可用于风险分层的主要临床工具。此外， 内部心脏逆转表纤维（ICD）放置是高风险患者的唯一有效疗法。 因此，研究心律不齐的新工具的鉴定在体内和分层心律失常风险将 代表了心血管护理的重大进步。 通过先驱奖的资助，我们将开发两种小说和革命性的技术 为完整的心脏中的电活动图像。首先，我们将适应最常见的临床 成像技术，二维多普勒超声心动图，以实时检测电活动。 其次，我们将开发一种修饰的自体干细胞植入物，以检测 心。这些技术将在体外开发，使用动物模型在体内测试，并应用于 人类在可能的情况下。如果成功，这两种技术都会增加我们对心律不齐的理解 机制，改善患有猝死风险的患者的风险分层，并引导治疗 干预措施。

项目成果

Magnetic Resonance Imaging of Contracting Ultrathin Cardiac Tissue.

收缩超薄心肌组织的磁共振成像。

• DOI: 10.1088/2057-1976/ab1c1c
• 发表时间: 2019
• 期刊: Biomedical physics & engineering express
• 影响因子: 1.4
• 作者: Shusterman,Vladimir;Nagpal,Prashant;Thedens,Daniel;Zhu,Xiaodong;Matasic,DanielS;Yoon,Jin-Young;Morgan,Gina;Hoffman,Stacy;London,Barry
• 通讯作者: London,Barry