Proposal to develop an inexpensive commercial process for the immobilization of l

建议开发一种廉价的商业化方法来固定 l

• 批准号: 8127415
• 负责人: Rod Phillip Musselman
• 金额: $ 14.68万
• 依托单位: CARNOW CONIBEAR AND ASSOCIATES, LTD
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2012-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8127415
• 关键词: Affect; Appearance; Area; Awareness; Bioavailable; Businesses; Centers for Disease Control and Prevention (U.S.); Chicago; Child; Clinical; Clinical effectiveness; Communities; Conduct Disorder; Disadvantaged; Disease; Ensure; Equipment; Esthetics; Evaluation; Family; Funding; Gypsum; Hazardous Waste; Hazardous Waste Sites; Health; Home environment; Housing; Immobilization; In Situ; Lead; Lead Poisoning; Life; Local Government; Measures; Methods; Modeling; Municipalities; Odors; Phase; Phosphorus; Pollution; Price; Private Sector; Process; Public Housing; Public Sector; Research; Risk; Running; Safety; Schools; Soil; Solid; Stream; Surveys; Techniques; Technology; Testing; Time; Universities; Water; Work; authority; base; blood lead; cost; hazard; inorganic phosphate; interest; landfill; lead exposure; prevent; primary outcome; product development; remediation; superfund site; urban area; wasting

DESCRIPTION (provided by applicant): The object of this project is to reduce the risk of lead poisoning in children by developing an inexpensive, commercially viable product which permanently reduces soluble (bioavailable) lead levels in soils. Young children in areas with lead-contaminated soil often have blood lead levels exceeding the CDC clinical action level. Elevated blood lead levels in children have been correlated with deleterious impacts later in life, including decreased IQ, increased arrest rates and conduct disorder. Phosphorus is an accepted technique for the immobilization of soluble lead in soil. However, the use of phosphorus can create phosphate leaching and run-off pollution. The addition of gypsum is proposed to mitigate phosphate impacts. Research will consist of bench-scale testing of gypsum and phosphate compounds mixed with water and lead-contaminated soil. Several application and mixing methods will be evaluated. The resulting mixtures will be tested for percentages of total and soluble lead (Pb) and total and leachable phosphorus (P). The standard for clinical effectiveness will be derived from the EPA model predicting a child's blood lead level based on soluble lead levels in soil. Additional evaluation factors will include the time to complete remediation, remediation cost, product safety issues, and aesthetic concerns (e.g. odor). A consumer interest survey will be conducted for potential users, including homeowners, businesses and local government. The survey will measure lead awareness, interest in lead remediation, price points and perceived barriers to use. The primary outcome of the project will be the selection of the best combination of an effective in situ treatment product with potential buyers' interest in using the product.

描述（由申请人提供）：该项目的目的是通过开发廉价，可行的可行产品来降低儿童铅中毒的风险，该产品永久降低土壤中的可溶性（生物利用）铅水平。 在铅污染土壤的地区，幼儿的血铅水平通常超过CDC临床作用水平。 儿童的血液铅水平升高与以后生活中的有害影响相关，包括智商降低，逮捕率提高和行为障碍。磷是一种可溶性铅在土壤中固定的公认技术。 但是，磷的使用可以产生磷酸盐浸出和径流污染。 提出了石膏的添加以减轻磷酸盐的影响。研究将包括石膏和磷酸盐化合物与水和铅污染土壤混合的台式测试。 将评估几种应用和混合方法。 所得的混合物将测试总铅和可溶性铅（PB）以及总磷（P）的百分比。 临床有效性的标准将源自EPA模型，该模型根据土壤中的可溶性铅水平来预测儿童的血铅水平。 其他评估因素将包括完成补救，补救成本，产品安全问题和美学问题的时间（例如气味）。 将针对包括房主，企业和地方政府在内的潜在用户进行消费者兴趣调查。 该调查将衡量铅意识，对铅修复的兴趣，价格点和可感知的使用障碍。 该项目的主要结果将是选择有效的原位治疗产品的最佳组合，并具有潜在买家对使用该产品的兴趣。