PROMOTER CHARACTERIZATION OF THE CART GENE

Cart 基因的启动子特征

• 批准号: 8357398
• 负责人: MICHAEL J KUHAR
• 金额: $ 3.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357398
• 关键词: Animals; Behavioral; Brain; Funding; Genes; Grant; Injection of therapeutic agent; National Center for Research Resources; Peptides; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; Viral; cocaine- and amphetamine-regulated transcript protein; cost; particle; promoter; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Most studies of CART peptides involve injecting the peptide into the brain and studying its effects. Therefore, this complementary project aimed at reducing endogenous CART was initiated. Several siRNAs have been found that, in preliminary experiments, reduce CART peptide levels. Also, injection of viral particles that will express siRNAs long term has been carried out. Useful behavioral studies are being carried out in animals where CART peptide levels have been reduced.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 大多数CART肽的研究都涉及将肽注入大脑并研究其作用。 因此，旨在减少内源性手推车的补充项目。 已经发现，在初步实验中，已经发现了一些siRNA降低卡特肽水平。同样，还进行了长期表达siRNA的病毒颗粒的注射。在降低的动物中，正在进行有用的行为研究。