Cardiac Physiology and Imaging Core for Mouse in Vivo

小鼠体内心脏生理学和成像核心

• 批准号: 8111954
• 负责人: KIRK L PETERSON
• 金额: $ 31.07万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8111954
• 关键词: Area; Cardiac; Cardiac Catheterization Procedures; Cardiovascular Diseases; Core Facility; Echocardiography; Engineering; Exercise; Gene Transfer; Goals; Heart failure; Hypertrophy; Image; Individual; Left; Magnetic Resonance Imaging; Methods; Modeling; Monitor; Morphology; Mus; Myocardial Infarction; Performance; Physiological; Physiology; Research Personnel; Right ventricular structure; Stress; Ventricular Remodeling; gene function; hemodynamics; in vivo; microangiography; pressure; programs

Introduction The goals of this core facility are to serve all of the investigators and projects within this Program Project in three major areas: 1. Provide heart catheterization, treadmill stress exercise performance, and telemetric hemodynamic monitoring for detailed physiologic characterization, as well as transthoracic echocardiography, magnetic resonance imaging and iodinated contrast microangiography for functional cardiac morphology, of genetically engineered murine models of cardiovascular disease. 2. Apply microsurgical methods in mice for inducing a pressure overload on either the left or right ventricle, or to produce myocardial infarction, in order to induce ventricular remodeling with hypertrophy or heart failure. 3. Induce high efficiency in vivo cardiac gene transfer in mice, where needed, to assess individual gene function.

介绍 该核心设施的目标是为该计划项目中的所有研究人员和项目提供服务 三大领域： 1. 提供心导管检查、跑步机压力运动表现、遥测血流动力学 监测详细的生理特征，以及经胸超声心动图、磁 磁共振成像和碘造影微血管造影用于功能性心脏形态学、遗传性 心血管疾病的工程小鼠模型。 2. 在小鼠中应用显微外科方法诱导左心室或右心室压力超负荷，或 产生心肌梗塞，从而诱发心室重构伴肥厚或心力衰竭。 3. 在需要时在小鼠体内诱导高效心脏基因转移，以评估个体基因 功能。