THE EFFECTS OF DOXAZOSIN ON THE CARDIOVASCULAR AND SUBJECTIVE EFFECTS OF COCAINE

多沙唑嗪对心血管的影响和可卡因的主观影响

• 批准号: 8356781
• 负责人: Thomas Frederick Newton
• 金额: $ 1.07万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356781
• 关键词: Cardiovascular system; Clinical Research; Cocaine; Double-Blind Method; Doxazosin; Enrollment; Evaluation; Funding; Grant; Hospitals; Informed Consent; Inpatients; Intravenous; Measures; National Center for Research Resources; Phase; Placebo Control; Placebos; Principal Investigator; Randomized; Research; Research Infrastructure; Resources; Route; Screening procedure; Smoke; Source; United States National Institutes of Health; cocaine use; cost; interest; meetings; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This will be a double-blind, placebo-controlled, within-subject, inpatient evaluation of potential interactions between intravenous cocaine and doxazosin. Interested candidates who have used cocaine by the smoked intravenous route in the past two weeks and are not seeking treatment, and are available for the 28 days of confinement as a hospital inpatient in the General Clinical Research Center (GCRC), will receive an explanation of the study purpose and requirement. If interested, the candidates will be allowed to review, inquire about and sign the informed consent. After providing signed informed consent, subjects proceed to the screening assessment phase of the study. If subjects meet all entry criteria, they will be enrolled and randomized into the study. Nontreatment-seeking cocaine dependent volunteers will be randomized to receive placebo (n=10) or doxazosin (n=10). Cardiovascular measures and subjective effects ratings will be assessed following cocaine administration.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 这将是对静脉注射可卡因和多沙唑嗪之间潜在相互作用的双盲、安慰剂对照、受试者内部、住院患者评估。过去两周内通过吸食静脉途径吸食可卡因且未寻求治疗且可在综合临床研究中心 (GCRC) 住院 28 天的感兴趣候选人将收到以下解释： 学习目的和要求。如有兴趣，候选人将被允许查看、询问并签署知情同意书。在提供签署的知情同意书后，受试者进入研究的筛选评估阶段。如果受试者符合所有进入标准，他们将被登记并随机进入研究。非寻求治疗的可卡因依赖志愿者将被随机分配接受安慰剂 (n=10) 或多沙唑嗪 (n=10)。可卡因给药后将评估心血管指标和主观效应评级。