NATIONAL REGISTRY OF GENETICALLY TRIGGERED THORACIC AORTIC ANEURYSMS

国家基因触发胸主动脉瘤登记处

• 批准号: 8356739
• 负责人: SCOTT A LEMAIRE
• 金额: $ 0.24万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356739
• 关键词: Aneurysm; Aortic Aneurysm; Aortic Rupture; Bioinformatics; Blood specimen; Cardiovascular system; Characteristics; Clinical; Clinical Management; Clinical Research; Data; Data Analyses; Development; Dissection; Equipment and supply inventories; Funding; Genetic; Goals; Grant; Medical; Methods; National Center for Research Resources; Operative Surgical Procedures; Outcome; Patients; Principal Investigator; Publishing; Registries; Research; Research Infrastructure; Research Personnel; Resources; Risk; Source; Specimen; Thoracic Aortic Aneurysm; Tissue Sample; United States National Institutes of Health; cost; interest; patient registry; repaired; tissue processing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall objective of GenTAC is to establish a registry of patients with genetically induced thoracic aortic aneurysms and related conditions, and collect associated medical data, as well as blood and tissue samples. The registry will establish a biospecimen inventory and bioinformatics infrastructure that will enable research to determine best medical practices to advance the clinical management of genetic thoracic aortic aneurysms, and other cardiovascular complications. To achieve these goals the registry will: 1) Develop standard methods to collect data and specimens which will be used for research to characterize patients at risk for aortic rupture and dissection, and development of other cardiovascular complications. 2) Record the characteristics of patients undergoing surgical repair of aneurysms and their clinical outcomes 3) Process tissue and blood specimens 4) Analyze data collected 5) Provide access to these resources to Registry investigators and outside researchers who are interested in advancing the fundamental understanding of genetic aortic aneurysms and management of afflicted patients 6) Publish and disseminate results.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 GENTAC的总体目的是建立具有遗传诱导的胸动脉瘤和相关状况的患者的注册表，并收集相关的医疗数据以及血液和组织样本。该注册中心将建立生物测量库存和生物信息学基础设施，该基础设施将使研究能够确定最佳医疗实践，以推动遗传胸部主动脉瘤的临床管理以及其他心血管并发症。为了实现这些目标，注册表将：1）开发标准方法来收集数据和标本，这些方法将用于研究，以表征有主动脉破裂和解剖风险的患者，以及开发其他心血管并发症。 2）记录接受手术修复动脉瘤及其临床结果的患者的特征3）处理组织和血液标本4）分析数据收集的数据5）提供了对这些资源的访问权限，以向注册研究人员和外部研究人员提供兴趣促进对遗传性动脉症的基本理解和对遗传患者的基本了解的感兴趣的研究人员6）出现和销量销量。