INFLUENCE OF DIET ON DEVELOPMENT OF INTESTINAL MICROBIOTA

饮食对肠道菌群发育的影响

• 批准号: 8356741
• 负责人: James Versalovic
• 金额: $ 2.05万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356741
• 关键词: Age; Asphyxia Neonatorum; Bacteria; Birth; Clinical Research; Comorbidity; Data; Development; Diet; Enrollment; Environment; Feces; Funding; Grant; Hospitals; Hour; Human Milk; Intestines; Methods; Milk; National Center for Research Resources; Necrotizing Enterocolitis; Neonatal Intensive Care Units; Premature Infant; Principal Investigator; Probiotics; Relative (related person); Research; Research Infrastructure; Resources; Sampling; Sepsis; Source; Texas; United States National Institutes of Health; cost; feeding; neonate; pathogen

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Background: The development of the intestinal microbiota is influenced by factors such as age, diet, and environment. There is limited data on intestinal bacterial colonization among hospitalized premature infants. Objectives: The study aims to describe and compare the development of intestinal microbiota among hospitalized premature infants receiving different types of milk. Methods: Neonates weighing 1000-1500 grams admitted to Texas Childrens Hospital Neonatal Intensive Care Unit (TCH NICU) within the first forty-eight hours from birth will be enrolled in the study. Neonates with congenital anomalies and perinatal asphyxia will be excluded. There will be three groups of neonates namely: expressed breast milk group, donor milk group and the formula milk group. Stool samples will analyzed for types of bacteria and relative amounts of bacteria over a period of six weeks. Expressed breast milk will be evaluated for presence of bacteria with probiotic potential and for pathogen. The occurrence of co-morbidities such as feeding intolerance, early and late onset sepsis and necrotizing enterocolitis will be compared among the three groups.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 背景：肠道菌群的发展受年龄，饮食和环境等因素的影响。住院过早的婴儿中肠道细菌定殖的数据有限。目的：该研究旨在描述和比较接受不同类型牛奶的住院过早婴儿肠道菌群的发展。 方法：在从出生后的第48个小时内入学的德克萨斯儿童医院新生儿重症监护病房（TCH NICU），重量为1000-1500克的新生儿将纳入研究。先天性异常和围产期窒息的新生儿将被排除。将有三组新生儿：表达的母乳组，供体牛奶组和配方奶牛奶组。粪便样品将在六周内分析细菌类型和细菌的相对量。将评估表达的母乳，以了解具有益生菌潜力和病原体的细菌。这三组将比较合并症，例如喂养不耐受，早期和晚期败血症和坏死性小肠结肠炎等合并症的发生。