X8 Prospector for Macromolecular Crystallography

X8 Prospector 用于高分子晶体学

• 批准号: 8051413
• 负责人: THOMAS D. HURLEY
• 金额: $ 45.33万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8051413
• 关键词: 16 year old; Aging; Alcoholism; Anodes; Biochemistry; Cardiovascular Diseases; Crystallography; Diabetes Mellitus; Disease; Environment; Faculty; Foundations; Foxes; Funding; Grant; HRH2 gene; Health; Indiana; Lead; Malignant Neoplasms; Molecular Biology; Molecular Structure; Neurodegenerative Disorders; Play; Proteins; Request for Applications; Research; Research Personnel; Research Support; Role; System; Therapeutic; United States National Institutes of Health; Universities; X-Ray Crystallography; drug discovery; improved; instrumentation; macromolecule; medical schools; member; tool

DESCRIPTION (provided by applicant): This S10 application requests funds for a Bruker X8 Prospector integrated diffraction system along with an Oxford cryostream to replace the aging system within the Department of Biochemistry and Molecular Biology at the Indiana University School of Medicine. The user group consists of 6 major users, 4 of whom are NIH funded investigators with 10 active grants and an additional 5 pending NIH grants. In addition, two new outstanding new faculty members with national-level funding from AHA and NSF, as well as the Michael J. Fox Foundation are part of the user group. X-ray crystallography is a powerful tool for the study of macromolecular structure. The research supported by this instrumentation request will lead to a better understanding of the roles our target proteins play in health and disease. Many of our major users are also involved in drug discovery research, which may ultimately lead to improved therapeutic approaches to treat diseases such as alcoholism, cardiovascular disease, diabetes, neurodegenerative disorders and cancer. The new instrumentation will be integrated into our existing X- ray crystallography facility by replacing the over 16 year-old H2R rotating anode generator. The upgrade of our facilities will allow our productive research faculty to remain competitive in the NIH funding environment and will undoubtedly lead to new advances in our understanding of the function of biomedically relevant macromolecules. PUBLIC HEALTH RELEVANCE: X-ray crystallography is a powerful tool for the study of macromolecular structure. The research supported by this instrumentation request will lead to a better understanding of the roles our target proteins play in health and disease. Many of our major users are also involved in drug discovery research which may ultimately lead to improved therapeutic approaches for diseases such as alcoholism, cardiovascular disease, diabetes and cancer.

描述（由申请人提供）：此 S10 申请要求为 Bruker X8 Prospector 集成衍射系统以及 Oxford Cryostream 提供资金，以取代印第安纳大学医学院生物化学和分子生物学系内的老化系统。该用户组由 6 个主要用户组成，其中 4 名是 NIH 资助的研究人员，拥有 10 项活跃拨款和另外 5 项待决的 NIH 拨款。此外，两位获得 AHA 和 NSF 以及 Michael J. Fox 基金会国家级资助的杰出新教员也是该用户组的一部分。 X射线晶体学是研究大分子结构的有力工具。该仪器要求支持的研究将有助于更好地了解我们的目标蛋白在健康和疾病中发挥的作用。我们的许多主要用户还参与了药物发现研究，这可能最终导致改进治疗酗酒、心血管疾病、糖尿病、神经退行性疾病和癌症等疾病的治疗方法。新仪器将取代已有 16 年历史的 H2R 旋转阳极发生器，并集成到我们现有的 X 射线晶体学设施中。我们设施的升级将使我们富有成效的研究人员在 NIH 资助环境中保持竞争力，并且无疑将导致我们对生物医学相关大分子功能的理解取得新进展。 公众健康相关性：X 射线晶体学是研究大分子结构的有力工具。该仪器要求支持的研究将有助于更好地了解我们的目标蛋白在健康和疾病中发挥的作用。我们的许多主要用户还参与了药物发现研究，这可能最终改进酗酒、心血管疾病、糖尿病和癌症等疾病的治疗方法。