Covalent trapping of HIV-1 spikes for vaccine design using chemical tethers

使用化学链共价捕获 HIV-1 尖峰用于疫苗设计

• 批准号: 8291661
• 负责人: MICHAEL B ZWICK
• 金额: $ 47.38万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-08 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8291661
• 关键词: Acquired Immunodeficiency Syndrome; Acute; Affect; Affinity; Aldehydes; Amines; Animals; Antibodies; Antibody Formation; Antibody Specificity; Antigens; Arginine; Binding; Biological; Biological Assay; Carbohydrates; Cells; Characteristics; Chemical Structure; Chemicals; Chemistry; Cleaved cell; Complex; Data; Dissociation; Engineering; Epitopes; Esters; Feedback; Goals; Guanidines; HIV; HIV Envelope Protein gp120; HIV-1; Heterogeneity; Hydrazones; Immune system; Immunization; Infection; Knowledge; Lead; Lysine; Maps; Methods; Molecular; Molecular Conformation; Oryctolagus cuniculus; Peptides; Phenols; Process; Production; Property; Reaction; Serum; Side; Specificity; Structure; Succinimides; Surface; Technology; Testing; Tyrosine; Ursidae Family; Vaccine Design; Vaccines; Variant; Virion; Virus; Work; arm; crosslink; env Glycoproteins; functional group; gp160; immunogenicity; interest; neutralizing antibody; novel; particle; receptor; research study; small molecule; stoichiometry; vaccine development