ANTI-INFLAMMATORY EFFECTS OF TARGETING THE HDAC6/HSP90 PATHWAY

针对 HDAC6/HSP90 通路的抗炎作用

• 批准号: 8308760
• 负责人: Wayne William Hancock
• 金额: $ 20.94万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8308760
• 关键词: Acetylation; Acetyltransferase; Address; Adoptive Transfer; Adrenal Cortex Hormones; Allografting; American; Anti-Inflammatory Agents; Anti-inflammatory; Autoimmune Diseases; Autoimmunity; Blocking Antibodies; Canis familiaris; Cell physiology; Cells; Cellular Stress; Chromatin; Chronic; Client; Colitis; Complex; Crohn' s disease; Cytoplasm; DNA Methyltransferase; DNA Modification Methylases; Data; Deacetylase; Development; Disease model; Enzymes; Epigenetic Process; Excision; Exhibits; Experimental Models; Funding; Gene Expression; Gene Expression Regulation; Genetic Transcription; Graft Rejection; HDAC6 gene; HDAC7 histone deacetylase; Heat shock proteins; Heat-Shock Proteins 70; Heat-Shock Proteins 90; Histone Deacetylase Inhibitor; Histones; Immune; Immunocompetent; Immunosuppression; Immunosuppressive Agents; In Vitro; Incidence; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Inflammatory Response; Infusion procedures; Long-Term Effects; Lysine; Maintenance; Mediating; Modeling; Multiple Myeloma; Mus; Mutagenesis; Neurodegenerative Disorders; Nuclear; Organ Transplantation; Outcome; Pathway interactions; Patients; Physicians; Prize; Protein Isoforms; Proteins; Regulation; Regulatory T-Lymphocyte; Research; Resistance; Risk; Role; Scientist; TNF gene; Tail; Therapeutic Effect; Therapeutic Intervention; Toxic effect; Up-Regulation; Wild Type Mouse; Work; allograft rejection; base; cell motility; chromatin remodeling; clinical application; in vivo; inhibitor/antagonist; innovation; insight; interest; nephrotoxicity; novel therapeutics; oncology; post-transplant disease; prevent; protein misfolding; protein protein interaction; response; therapeutic development; therapeutic target; tumor