MicroRNAs as Molecular Effectors of Seizure-preconditioning

MicroRNA 作为癫痫预适应的分子效应器

• 批准号: 8334745
• 负责人: ROGER Pancoast SIMON
• 金额: $ 33.03万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8334745
• 关键词: Animals; Biogenesis; Brain; Brain Injuries; Cell Death; Cessation of life; Chronic; Complement; Data; Development; Epilepsy; Epileptogenesis; Experimental Models; Functional RNA; Gene Expression Profile; Generalized seizures; Hippocampus (Brain); In Situ; Ischemic Preconditioning; Lead; Lentivirus Vector; Long-Term Effects; Mediating; Messenger RNA; MicroRNAs; Molecular; Neurons; Pathway interactions; Process; Proteins; RNA-Induced Silencing Complex; Route; Seizures; Single Seizures; Status Epilepticus; Temporal Lobe Epilepsy; Therapeutic; Time; Translations; Work; acute stress; base; in vivo; mouse model; neuroprotection; novel; preconditioning; prevent; programs; response; spatiotemporal; uptake

项目成果

MicroRNA and epilepsy: profiling, functions and potential clinical applications.

• DOI: 10.1097/wco.0000000000000079
• 发表时间: 2014-04
• 期刊: Current opinion in neurology
• 影响因子: 4.8
• 作者: Henshall DC

Antagomirs and microRNA in status epilepticus.

• DOI: 10.1111/epi.12267
• 发表时间: 2013-09
• 期刊: Epilepsia
• 影响因子: 5.6
• 作者: Henshall DC

Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects.

• DOI: 10.1038/nm.2834
• 发表时间: 2012-07
• 期刊: NATURE MEDICINE
• 影响因子: 82.9
• 作者: Jimenez-Mateos, Eva M.;Engel, Tobias;Merino-Serrais, Paula;McKiernan, Ross C.;Tanaka, Katsuhiro;Mouri, Genshin;Sano, Takanori;O'Tuathaigh, Colm;Waddington, John L.;Prenter, Suzanne;Delanty, Norman;Farrell, Michael A.;O'Brien, Donncha F.;Conroy, Ronan M.;Stallings, Raymond L.;DeFelipe, Javier;Henshall, David C.
• 通讯作者: Henshall, David C.