2010 and 2012 Protein Folding Dynamics Gordon Research Conference and Graduate Re

2010年和2012年蛋白质折叠动力学戈登研究会议和研究生研究

• 批准号: 7996635
• 负责人: SUSAN MARQUSEE
• 金额: --
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-15 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7996635
• 关键词: Address; Aging; Area; Biophysics; California; Computer Simulation; Disease; Educational workshop; Funding; Genome; Goals; Health; Human Genome; Knowledge; Methodology; Methods; Modeling; Molecular Chaperones; Pathology; Postdoctoral Fellow; Preparation; Protein Dynamics; Research; Schedule; Scientist; Techniques; Variant; Vision; base; graduate student; meetings; polypeptide; protein folding; protein misfolding; public health relevance; research study; symposium; theories

DESCRIPTION (provided by applicant): The purpose of this proposal is to request funding to support the 5th and 6th Gordon Research Conference (GRC) on Protein Folding Dynamics and the accompanying Graduate Research Seminar (GRS) in Protein Folding Dynamics, which is a workshop for graduate students and post docs addressing the methods and models of protein folding. The 2010 meetings will take place at the Ventura Beach Marriott, Ventura, California from January 9-10 (GRS) and January 10-15 (GRC), 2010. The subsequent meeting will be scheduled for January 2012. The broad and long term goal of the conference is to bring together experiment and theory; it is a forum for discussion between experts in experimental biophysics and experts in theory and computer simulation. The conference will serve as a forum to discuss fundamental problems from polypeptide energetics and dynamics; to chaperone assisted folding and the relationship between protein misfolding and disease. The specific aims of the Graduate Research Seminar in Protein Folding Dynamics is to serve as a venue for graduate students and postdoctoral scientists to i) develop background on current techniques, theories and models in preparation for the GRC in Protein Folding Dynamics, ii) share their knowledge of protein folding methodologies and techniques and iii) meet each other and discuss their own research. The significance of this application is that the Graduate Research Seminar in Protein Folding Dynamics involvement and inclusion of young and developing scientists represents a key objective in our vision to provide this vibrant multi-disciplinary research area with scientists who are broadly based in both experimental protein folding methodologies and the models and theories that provide a basis for the interpretation of experiment in this field. PUBLIC HEALTH RELEVANCE: The health relatedness of this application is multifaceted. The discussions of current research in the field will directly apply to our understanding and treatment of the many misfolding diseases and the many pathologies and problems of aging that result from a loss of proteostasis. In a broader sense, the conference and workshop will have an impact on a mechanistic understanding to the variation in the human genome as most of the non-synonymous variation in the genome result in subtle changes in protein dynamics and energetics.

描述（由申请人提供）：本提案的目的是要求资金支持蛋白质折叠动力学和随附的蛋白质折叠式动力学研究生研究研讨会（GRS）的第五和第六届戈登研究会议（GRC），这是研究生的工作室，这是研究生的工作室，并在蛋白质折叠的方法和邮政文档中进行了文档。 2010年的会议将于1月9日至10日（GRS）和1月10日至15日（GRC）在2012年1月10日至15日（GRC）举行。它是一个论坛，在实验生物物理学专家与理论和计算机模拟专家之间进行讨论。该会议将作为一个论坛，讨论多肽能量和动态的基本问题；伴侣辅助折叠以及蛋白质错误折叠和疾病之间的关系。蛋白质折叠动力学研究生研究研讨会的具体目的是为研究生和博士后科学家提供i）的场所。该应用的重要性是，在蛋白质折叠动力学参与和纳入蛋白质折叠动力学和发展科学家的研究生研究研讨会上代表了我们的愿景中的一个关键目标，即提供这个充满活力的多学科研究领域，这些研究领域的科学家与实验蛋白质折叠方法和模型和理论相关的科学家提供了在该领域中解释实验的基础的模型和理论。 公共卫生相关性：该应用程序的健康相关性是多方面的。该领域当前研究的讨论将直接适用于我们对许多错误折叠疾病的理解和治疗，以及由于失去蛋白质的损失而导致的许多病理和衰老问题。从广义上讲，会议和研讨会将对人类基因组变异的机械理解产生影响，因为基因组的大多数非同义变化会导致蛋白质动力学和能量学的细微变化。