Mount Sinai Institutes for Clinical and Translational Sciences

西奈山临床和转化科学研究所

• 批准号: 8060556
• 负责人: Barbara T. Murphy
• 金额: $ 602.45万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-14 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8060556
• 关键词: Mount; Sinai; Institutes; Clinical; Translational

Despite great scientific advances over the past decade, the translation of these discoveries to the benefit of patients has been hampered by a number of traditional barriers. The overall goal of the Mount Sinai institutes of Clinical & Translational Sciences is to establish a new research paradigm at Mount Sinai, which will create an integrated multidisciplinary environment that will enable translation of cutting-edge research more quickly and easily from "bench-to-bedside-to-implementation" in the community; train and create an "academic home" for the clinical and translational investigators of tomorrow; and supply the governance, facilities, resources and opportunities needed to elevate the clinical research enterprise so that clinical investigators can take full advantage of Mount Sinai's Translational Research Institutes and potential collaborators in Mount Sinai Hospital and its affiliates, the School of Medicine and partnering institutions, and other CTSA programs around the country. This transformation will be achieved by fulfilling the following Specific Aims: (1) redesign the institutional research enterprise infrastructure and governance by integrating research functions across administrative, departmental and intellectual boundaries, enhancing and promoting interactions between basic scientists and clinical investigators, and streamlining administrative procedures to facilitate the start-up of clinical trials and the dissemination of results; (2) establish a Translational Discoveries Program to facilitate and expedite clinical research by providing consultation, oversight and facilities for clinical and translational research, engaging the surrounding community and our affiliates to rapidly translate health benefits to the general population, and developing new methodologies to improve clinical trial design and reduce participant burden; (3) train and support the translational investigators of tomorrow by overseeing a multi-disciplinary, doctoral degree-granting program in clinical and translational research for all health care professionals, developing a program to recruit, enhance career development and retain clinical and translational researchers, providing an academic home where new collaborations can be formulated; (4) establish an Experimental Therapeutics& Technologies Program to stimulate the development of new methodologies in clinical and translational research by developing an institution-wide mentored program to identify and develop novel clinical and translational research projects; and (5) establish an institution-wide biomedical information infrastructure that can connect basic researchers, clinical researchers, caregivers and laboratories with an integrated network of information. RELEVANCE (See instructions): The establishment ofthe Mount Sinai Institutes of Clinical & Translational Sciences would create an effective, efficient and centralized research administrative structure, foster and reward interdisciplinary collaborations, educate and retain the clinical and translational investigators of the future, enable translation of basic scientific discoveries into clinical practice, and deliver to our diverse community new therapies and a standard of care that would have been unimaginable even five years ago.

尽管过去十年取得了巨大的科学进步，但这些发现的转化却造福于人类 患者的治疗受到许多传统障碍的阻碍。西奈山的总体目标 临床与转化科学研究所将在西奈山建立一个新的研究范式， 这将创建一个综合的多学科环境，使尖端技术的翻译成为可能 在社区中更快速、更轻松地进行从“实验室到临床到实施”的研究；火车和 为未来的临床和转化研究人员创建一个“学术之家”；并提供 提升临床研究事业所需的治理、设施、资源和机会，以便 临床研究人员可以充分利用西奈山的转化研究所和潜力 西奈山医院及其附属机构、医学院和合作机构的合作者，以及 全国各地的其他 CTSA 计划。这一转变将通过满足以下条件来实现 具体目标：（1）通过整合重新设计机构研究企业基础设施和治理 跨越行政、部门和智力界限的研究职能，增强和 促进基础科学家和临床研究人员之间的互动，并简化行政管理 促进临床试验启动和结果传播的程序； (2)建立一个 转化发现计划通过提供咨询来促进和加速临床研究， 临床和转化研究的监督和设施，吸引周围社区和我们的 附属机构迅速将健康益处惠及普通大众，并开发新方法 改进临床试验设计，减轻参与者负担； (3) 培训和支持翻译 通过监督临床和临床领域的多学科博士学位授予项目，培养未来的研究人员 针对所有医疗保健专业人员的转化研究，制定招聘计划，提升职业生涯 培养并保留临床和转化研究人员，为新的学术家园提供 可以制定合作； (4) 建立实验治疗和技术计划 通过开发一种新的方法来刺激临床和转化研究新方法的发展 机构范围内的指导计划，以确定和开发新颖的临床和转化研究项目； (5) 建立全机构范围的生物医学信息基础设施，连接基础研究人员， 具有集成信息网络的临床研究人员、护理人员和实验室。 相关性（参见说明）： 西奈山临床与转化科学研究所的成立将创建一个 有效、高效和集中的研究管理结构，培育和奖励跨学科 合作、教育和留住未来的临床和转化研究人员、实现翻译 将基础科学发现转化为临床实践，并为我们多元化的社区提供新的疗法和 即使在五年前，这也是难以想象的护理标准。