CTSA INFRASTRUCTURE FOR CLINICAL TRIALS

CTSA 临床试验基础设施

• 批准号: 8365158
• 负责人: REZA NONE SHAKER
• 金额: $ 40.52万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365158
• 关键词: Award; Clinical Trials; Research Infrastructure; Translational Research

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. The National institutes of Health's RFA for Clinical and Translational Science Awards has catalyzed the efforts of academic medical institutions to remove impediments to the translation of fundamental discoveries into better health for our citizens and rectify shortages within the clinical and translational workforce. This proposal of the Clinical and Translational Science Institute of Southeast Wisconsin is tailored to the needs and resources of the biomedical enterprise in the region and offers a novel and transformative plan to achieve the above mentioned goals. Building on the long collaborative history among the major academic and healthcare institutions in our area, we have constructed a unique academic-community partnership comprised of the Medical College of Wisconsin, University of Wisconsin-Milwaukee, Marquette University, Milwaukee School of Engineering, Froedtert Hospital, Children's Hospital of Wisconsin, Zablocki VA Medical Center and BloodCenter of Wisconsin, set in the milieu of a large urban community with remarkable ethnic and social diversity. Our proposal brings together the various resources of the partner institutions to identify and address the obstacles that impede the conduct of clinical and translational research in the region. The transfonning environment of our CTSI focuses on the interdependency and interrelationship of our research teams and the relationship of the key functions to the rest of the CTSA in their integrating, enabling and effecting roles. To accomplish this transfonnation, we propose (and have begun to implement during the pre-award years) 1) To develop a distinct "Academic Home" for the discipline of clinical and translational science - the Clinical and Translational Science Institute (CTSI) - which transcends intra-and inter-institutional barrier, empowers experienced leadership to have the authority and resources to promote, facilitate, coordinate and foster the continuum of translational research from bench to bedside (Tl), to clinical practices (T2), and to our communities (T3); 2) To increase the number of investigators participating in clinical research through innovative programs within the CTSI; 3) To develop, align, and coordinate infrastructure across institutions to provide our scientists with the resources required for Clinical and Translational research; and 4) To engage clinical practices and the community in research h that enhances public health. Our Community Engagement program is an MCW strength. We will build on an existing network of the Healthier Wisconsin Partnership Program (HWPP) and expertise and resources of our partners in medical, biomedical engineering, dentistry, nursing, social sciences and allied health disiciplines to implement novel community based (T3) research programs. We believe our CTSA model is transferable to other similarly-sized academic research communities across the country. RELEVANCE (See instructions): Better preventive measures, more accurate diagnostics, and more effective therapies are badly needed to improve the health of our citizens. This application provides a novel and comprehensive mechanism to address these needs through research and education. It creates a borderless, collaborative environment in SE Wisconsin for biomedical researchers, healthcare providers, educators, citizens, and industry to work together synergistically and translate the fundamental discoveries into better health for our citizens.

该子项目代表CTSA资金百分比的估计值 被用于广泛的研究领域（艾滋病研究，儿科研究或 临床试验）。 列出的总成本只是CTSA数量的估计值 基础设施朝向这一研究领域，而不是直接提供的资金 NCRR授予subproject或subproject人员。 美国国立卫生研究院的临床和转化科学奖RFA促进了学术医疗机构的努力，以消除将基本发现转化为改善健康的障碍，并纠正临床和翻译员工中的短缺。威斯康星州东南部临床和转化科学研究所的这一建议是根据该地区生物医学企业的需求和资源量身定制的，并提供了一项新颖而变革性的计划，以实现上述目标。在我们地区主要的学术和医疗机构之间的悠久合作历史的基础上，我们建立了一个独特的学术社会社区伙伴关系具有非凡种族和社会多样性的大型城市社区。我们的建议汇集了合作伙伴机构的各种资源，以识别和解决阻碍该地区临床和转化研究的障碍。我们的CTSI的转变环境集中在我们的研究团队的相互依存和相互关系上，以及关键功能与CTSA其他CTSA的关系在整合，启用和有效的角色中。 To accomplish this transfonnation, we propose (and have begun to implement during the pre-award years) 1) To develop a distinct "Academic Home" for the discipline of clinical and translational science - the Clinical and Translational Science Institute (CTSI) - which transcends intra-and inter-institutional barrier, empowers experienced leadership to have the authority and resources to promote, facilitate, coordinate and foster the continuum of translational research from bench到床边（TL），临床实践（T2）和我们的社区（T3）； 2）通过CTSI内的创新计划来增加参与临床研究的研究人员的数量； 3）开发，结算和协调机构的基础设施，为我们的科学家提供临床和转化研究所需的资源； 4）在研究H中参与临床实践和社区，以增强公共卫生。我们的社区参与计划是MCW的力量。我们将建立在威斯康星州健康合作计划（HWPP）的现有网络上，以及我们合作伙伴在医学，生物医学工程，牙科，护理，社会科学和盟军健康疑虑方面的专业知识和资源，以实施基于新颖的社区（T3）研究计划。我们认为，我们的CTSA模型可以转移到全国其他类似规模的学术研究社区。相关性（请参阅说明）：非常需要更好的预防措施，更准确的诊断和更有效的疗法来改善我们的公民的健康。该应用程序提供了一种新颖而全面的机制，可以通过研究和教育来满足这些需求。它在威斯康星州为生物医学研究人员，医疗保健提供者，教育工作者，公民和行业创造了一个无边界的协作环境，以协同合作，将基本​​发现转化为对我们的公民更好的健康。