Canada East and West Network

加拿大东西部网络

基本信息

批准号：
7475116
负责人：
jean-lucien rouleau
金额：
$ 26.22万
依托单位：
MONTREAL HEART INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-30 至 2011-06-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Congestive heart failure is a major health problem that afflicts close to 1.5% of the population of the US and Canada. Patients with congestive heart failure have significantly reduced survival and quality of life. Multiple new strategies for the treatment of congestive heart failure are being developed, many of them involving complex strategies, including some that hope to regenerate the heart. Progress in transforming these treatment strategies from ideas to clinical practice is hampered by a lack of a network of sophisticated clinical researchers possessing the infrastructure required to test these complex strategies. The NIH has decided to form a Heart Failure Research Network of to address this challenge. The Canadian East-West Network is proposing to join the NIH Network to help it attain its goals of bringing innovative experimental strategies for the treatment of heart failure from the laboratory to the bedside. The Canadian East-West Network is made up of 19 university hospital centers, 7 large regional hospital centers, and 18 regional hospital centers. Together they treat over 10,000 patients with heart failure, of which around 25% are new patients a year. Their university hospital centers have the sole tertiary responsibility for 13.5 million people, and share in the tertiary care responsibility of another 10 million people. All major hospitals caring for the 8 million people in the province of Quebec take part in the Network. The Canadian East-West Network has a number of special attributes, and brings with it expertise that would be helpful to the NIH network as a whole. Its members belong to a single payer socialized medical system, which facilitates patient follow-up and data generation. It has a long and successful tradition of working with the NIH, it has an experienced clinical research coordinating center, and some of its members have worked successfully as a network for nearly twenty years. The Canadian East-West Network brings with it a web-based electronic patient record that it has developed and is willing to share, a cutting edge pharmacogenomics center, expertise in blood sampling, transportation and measurement, and two implantable artificial heart programs. The Canadian East-West Network proposes a project using pharmacogenomics to identify which patients are most and least likely to benefit from a given medication, and a second project that will compare the ability of two types of a patients own stem cells in regenerating their heart after a large myocardial infarction (heart attack). (End of Abstract)

描述（由申请人提供）：充血性心力衰竭是一个主要的健康问题，困扰着美国和加拿大近 1.5% 的人口。充血性心力衰竭患者的生存率和生活质量显着降低。多种治疗充血性心力衰竭的新策略正在开发中，其中许多涉及复杂的策略，包括一些希望使心脏再生的策略。由于缺乏拥有测试这些复杂策略所需基础设施的成熟临床研究人员网络，将这些治疗策略从想法转变为临床实践的进展受到阻碍。美国国立卫生研究院 (NIH) 决定成立心力衰竭研究网络来应对这一挑战。加拿大东西方网络提议加入 NIH 网络，以帮助其实现将心力衰竭治疗的创新实验策略从实验室带到临床的目标。加拿大东西方网络由 19 个大学医院中心、7 个大型地区医院中心和 18 个地区医院中心组成。他们共同治疗了 10,000 多名心力衰竭患者，其中每年约 25% 是新患者。他们的大学医院中心单独承担 1,350 万人的三级医疗责任，并分担另外 1,000 万人的三级医疗责任。为魁北克省 800 万人提供医疗服务的所有主要医院都加入了该网络。加拿大东西方网络具有许多特殊属性，并带来了对整个 NIH 网络有帮助的专业知识。其成员属于单一付款人社会化医疗系统，有利于患者随访和数据生成。它拥有与 NIH 合作的悠久而成功的传统，拥有经验丰富的临床研究协调中心，其一些成员已经作为一个网络成功地工作了近二十年。加拿大东西方网络带来了其开发并愿意分享的基于网络的电子病历、尖端的药物基因组学中心、血液采样、运输和测量方面的专业知识，以及两个植入式人工心脏项目。加拿大东西方网络提出了一个项目，利用药物基因组学来确定哪些患者最有可能从某种药物中受益，而第二个项目将比较两种类型患者自身干细胞在心脏再生后的能力。大面积心肌梗塞（心脏病发作）。（摘要完）