COBRE: UID: PILOT: SELENIUM HOMEOSTASIS AND ANXIETY: THE ROLE OF THE GENOTYPE

COBRE：UID：飞行员：硒稳态和焦虑：基因型的作用

• 批准号: 8167457
• 负责人: BARRIE D ROBISON
• 金额: $ 8.27万
• 依托单位: UNIVERSITY OF IDAHO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167457
• 关键词: Animal Model; Anxiety; Behavior; Biological Models; Brain; Computer Retrieval of Information on Scientific Projects Database; Conflict (Psychology); Environment; Funding; Genetic; Genetic Variation; Genotype; Grant; Homeostasis; Human; Individual; Institution; Link; Medical; Medicine; Mental Health; Moods; Neurologic; Physiological; Population; Research; Research Personnel; Resources; Role; Selenium; Source; Supplementation; Trace Elements; United States National Institutes of Health; Vertebrates; Zebrafish; base; interest; response; selenium deficiency

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Selenium (Se) is an essential trace element that is critical for maintaining normal brain function in humans and other vertebrates. Se deficiency causes numerous neurological and physiological deficits, eliciting considerable interest regarding the potential benefits of Se supplementation. In particular, there is some evidence that Se supplementation has beneficial mental health effects in humans, including decreased anxiety. However, the effects of Se supplementation on human behavior and mood are controversial; while several studies have linked Se status to anxiety, others have found no such effect. We hypothesize that a genotype by environment interaction may explain the conflicting results regarding the efficacy of Se supplementation in humans. While the concept of a genotype by environment interaction is not new to evolutionary biologists, genetic variation among individuals and populations is only now becoming a key factor in effective medical treatment (i.e. "personalized medicine"). Studying the genetic basis and evolutionary relevance of genetic variation in the response to Se supplementation is difficult in humans, necessitating an approach using model organisms. Here we argue that our behaviorally distinct strains of zebrafish are the ideal model system in which the genetic basis of a population specific response to Se supplementation can be studied.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 硒 (Se) 是一种必需的微量元素，对于维持正常的大脑功能至关重要 在人类和其他脊椎动物中。硒缺乏会导致许多神经和生理问题 缺陷，引起了人们对补充硒的潜在好处的极大兴趣。在 特别是，有一些证据表明补充硒对心理健康有益 对人类来说，包括减少焦虑。然而，补硒对人体的影响 行为和情绪有争议；虽然一些研究已将硒状态与焦虑联系起来， 其他人则没有发现这样的效果。 我们假设环境相互作用的基因型可以解释相互矛盾的结果 关于补充硒对人体的功效。虽然基因型的概念 环境相互作用对于进化生物学家来说并不新鲜，个体之间的遗传变异 个人和人群现在才成为有效医疗的关键因素 （即“个性化医疗”）。研究遗传的遗传基础和进化相关性 人类对补充硒的反应很难发生变化，因此需要 使用模式生物的方法。在这里，我们认为我们行为上不同的菌株 斑马鱼是理想的模型系统，其中群体特异性反应的遗传基础 可以研究补充硒。