COBRE: WVU: SIGNAL TRANSDUCTION & CANCER: ADMINISTRATIVE CORE

COBRE：西弗吉尼亚大学：信号传导

• 批准号: 8167955
• 负责人: Laura F. Gibson
• 金额: $ 33.06万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167955
• 关键词: Address; Affect; Appalachian Region; Basic Science; Bioinformatics; Cancer Center; Cervical; Clinical Cancer Center; Computer Retrieval of Information on Scientific Projects Database; Core Facility; Faculty; Flow Cytometry; Fostering; Funding; Goals; Grant; Head and neck structure; Image; Institution; Lung; Malignant Neoplasms; Mentors; Ovarian; Phase; Pilot Projects; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Signal Transduction; Source; Translational Research; United States National Institutes of Health; Universities; West Virginia; health disparity; malignant breast neoplasm; meetings; member; patient population; programs; protein purification

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cancer disproportionately affects the citizens of West Virginia and Appalachia, as evidenced by health disparities in cervical, lung, head & neck, ovarian and breast cancers. The Mary Babb Randolph Cancer Center (MBRCC) was established at West Virginia University to address this problem. Toward that goal we will establish a cancer center that meets the criteria for NCI designation as a Clinical Cancer Center. In Phase I of our CoBRE funding the MBRCC coordinated cancer center membership and organization of programs, provided matching support for pilot projects, core facilities and lab/office space for new faculty hires. In addition, the CoBRE provided support for five junior faculty research projects, core facility infrastructure and matching funds for faculty recruitment. We successfully recruited 8 faculty members, mentoring 5 junior faculty to independent research project grant (RPG) funding, establishing two new core facilities and expanding the scope of a 3rd core facility. During Phase II we have sought to add depth to our basic science research programs with a long term goal of integrating basic research projects with translational research programs. During the coming year our specific aims include (a) continuation of our Administration Core, (b) support core facilities in Flow Cytometry, Bioinformatics, Imaging and Protein Purification and (c) support five junior faculty research projects and mentor these faculty members to independence. This CoBRE program will foster our long term goal of achieving NCI designation as a Clinical Cancer Center that serves the patient population of West Virginia and the surrounding Appalachian region.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 癌症对西弗吉尼亚州和阿巴拉契亚地区居民的影响尤为严重，宫颈癌、肺癌、头颈癌、卵巢癌和乳腺癌的健康差异就证明了这一点。西弗吉尼亚大学成立了玛丽·巴布·伦道夫癌症中心（MBRCC）来解决这个问题。 为了实现这一目标，我们将建立一个符合 NCI 指定为临床癌症中心标准的癌症中心。 在我们的 CoBRE 资助的第一阶段，MBRCC 协调了癌症中心的成员资格和项目组织，为试点项目、核心设施和新聘教员的实验室/办公空间提供了配套支持。 此外，CoBRE 还为五个初级教师研究项目、核心设施基础设施和教师招聘配套资金提供支持。 我们成功招募了 8 名教职人员，指导 5 名初级教职人员获得独立研究项目补助金 (RPG) 资助，建立了两个新的核心设施，并扩大了第三个核心设施的范围。 在第二阶段，我们寻求增加基础科学研究项目的深度，长期目标是将基础研究项目与转化研究项目相结合。 在来年，我们的具体目标包括（a）继续我们的管理核心，（b）支持流式细胞术、生物信息学、成像和蛋白质纯化方面的核心设施，以及（c）支持五个初级教师研究项目并指导这些教师独立。该 CoBRE 计划将促进我们的长期目标，即实现 NCI 指定为临床癌症中心，为西弗吉尼亚州和周边阿巴拉契亚地区的患者群体提供服务。