Neuromorphometry of Psychosis in Bipolar Disorder

双相情感障碍精神病的神经形态测量

基本信息

批准号：
7991854
负责人：
DANIEL MAMAH
金额：
$ 17.12万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-12-01 至 2014-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7991854
关键词：
22q12 Affect Anatomy Anisotropy Area Basal Ganglia Biological Bipolar Disorder Brain Brain Mapping Brain Pathology Brain region Characteristics Classification Clinical Corpus Callosum Databases Development Diagnostic Diffusion Magnetic Resonance Imaging Disease Doctor of Philosophy Dopamine Receptor Education Epidemiology Etiology Family Functional disorder Funding Future Genetic Grant Hallucinations Hippocampus (Brain)Knowledge MRI Scans Maps Measures Memory impairment Mentors Methodology Metric Molecular Genetics Neurobiology Patients Pharmaceutical Preparations Positron-Emission Tomography Postdoctoral Fellow Predisposition Principal Investigator Psychiatric Diagnosis Psychiatry Psychopathology Psychotic Disorders Published Comment Radiology Specialty Reporting Research Research Ethics Research Methodology Residencies Resolution Risk Running Scanning Schizophrenia Severities Shapes Short-Term Memory Structure Susceptibility Gene Syndrome Thalamic structure Training United States National Institutes of Health Universities Washington base clinical practice computational anatomy disease classification disorder subtype endophenotype experience gray matter imaging modality improved interest medical schools neuroimaging programs public health relevance tool white matter

22q12 Affect Anatomy Anisotropy Area Basal Ganglia Biological Bipolar Disorder Brain Brain Mapping Brain Pathology Brain region Characteristics Classification Clinical Corpus Callosum Databases Development Diagnostic Diffusion Magnetic Resonance Imaging Disease Doctor of Philosophy Dopamine Receptor Education Epidemiology Etiology Family Functional disorder Funding Future Genetic Grant Hallucinations Hippocampus (Brain)Knowledge MRI Scans Maps Measures Memory impairment Mentors Methodology Metric Molecular Genetics Neurobiology Patients Pharmaceutical Preparations Positron-Emission Tomography Postdoctoral Fellow Predisposition Principal Investigator Psychiatric Diagnosis Psychiatry Psychopathology Psychotic Disorders Published Comment Radiology Specialty Reporting Research Research Ethics Research Methodology Residencies Resolution Risk Running Scanning Schizophrenia Severities Shapes Short-Term Memory Structure Susceptibility Gene Syndrome Thalamic structure Training United States National Institutes of Health Universities Washington base clinical practice computational anatomy disease classification disorder subtype endophenotype experience gray matter imaging modality improved interest medical schools neuroimaging programs public health relevance tool white matter

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项目摘要

DESCRIPTION (provided by applicant): Although current nosology defines schizophrenia (SCZ) and bipolar disorder as unique constructs with distinctive clinical characteristics, there exist significant symptomatic and familial overlap. Epidemiologic and genetic studies suggest that SCZ shares common susceptibility genes with psychotic bipolar disorder (PBD), as opposed to nonpsychotic bipolar disorder (NPBD), suggesting that they may also share similar structural abnormalities in gray and white matter in the brain. We hypothesize that: 1) PBD and NPBD will differ in measures of subcortical gray matter and white matter integrity, 2) abnormalities in PBD will be intermediate between SCZ and NPBD, and 3) there will be a significant relationship between lifetime psychosis severity and structural measures. The Aims of this proposal are to: 1) collect MRI scans from 40 PBD and 40 NPBD subjects and generate volume and shape metrics for the hippocampus, thalamus and basal ganglia, and measures of corpus callosum integrity, 2) compare these measures between PBD, NPBD, SCZ and controls, and 3) correlate lifetime psychopathology with structural abnormalities in PBD and SCZ. This 5-year program will involve training in specific neuroimaging methodologies and the neurobiology of bipolar disorder, as well as general research and ethics. Imaging methods used in this proposal will be Large-Deformation High-Dimensional Brain Mapping and Diffusion Tensor Imaging. Deanna Barch, Ph.D. (Dept. of Psychiatry, Washington University), John Csernansky, MD (Northwestern University), Joshua Shimony, MD, PhD and Abraham Snyder, PhD, MD (both at the Dept. of Radiology, Washington University) will co-mentor the principal investigator's scientific development. All co-mentors have substantial experience in various areas of neuroimaging and in the application of related research methods, as well as experience training postdoctoral fellows and NIH grant recipients. The proposal is also supported by a rich diversity of collaborators and consultants to provide education and guidance in various aspects of research. The principal investigator has completed residency training in Psychiatry and a Masters in Psychiatric Epidemiology (MPE) at Washington University School of Medicine in St. Louis. PUBLIC HEALTH RELEVANCE: In clinical practice, treatments used in schizophrenia and bipolar disorder often overlap, and selected medications are not effective in all those affected by these disorders. Identification of specific structural brain abnormalities that cross traditional diagnostic boundaries, as is proposed, would allow for the development of more specific treatments for those affected, and identify those at risk. Specific biological abnormalities will also help validate psychiatric diagnoses and improve the classification of disorders.

描述（由申请人提供）：尽管当前的疾病学将精神分裂症（SCZ）和躁郁症定义为具有独特临床特征的独特结构，但存在明显的症状和家族重叠。流行病学和遗传学研究表明，与非精神病性双相情感障碍（NPBD）相比，SCZ具有具有精神病性躁郁症（PBD）的共同易感基因（PBD），这表明它们也可能在大脑中具有相似的结构异常。我们假设：1）PBD和NPBD在皮层灰质和白质完整性的度量方面将有所不同，2）PBD的异常将中间介于SCZ和NPBD之间，而3）生命周期的精神病严重程度和结构测量之间将存在显着的关系。该提案的目的是：1）从40个PBD和40个NPBD受试者中收集MRI扫描，并为海马，丘脑和基础神经节生成体积和形状指标，以及corb症callosum callosimeftimity的度量，2）与PBD，NPBD，SCZ和3）相关性和3）相关性的措施进行比较。 SCZ。这个为期5年的计划将涉及在特定的神经影像学方法和躁郁症的神经生物学以及一般研究和伦理学方面的培训。该建议中使用的成像方法将是大型信息高维大脑映射和扩散张量成像。 Deanna Barch博士（华盛顿大学精神病学系），医学博士John Csernansky（西北大学），医学博士Joshua Shimony，博士和Abraham Snyder，博士，医学博士（均为华盛顿大学放射学系），将共同参与主要研究员的科学研究者的科学开发。所有副主持人在神经影像的各个领域以及相关研究方法的应用以及培训博士后研究员和NIH赠款接受者方面都有丰富的经验。该提案还得到了许多合作者和顾问的多样性的支持，以在研究的各个方面提供教育和指导。这位主要研究人员已完成精神病学的住院医师培训，并在圣路易斯华盛顿大学医学院的精神病学硕士学位（MPE）完成了精神病学硕士学位。公共卫生相关性：在临床实践中，精神分裂症和躁郁症中使用的治疗经常重叠，并且选定的药物在所有受这些疾病影响的药物中均无效。鉴定特定的结构性脑异常，这些异常跨越传统的诊断边界，这将允许为受影响的人开发更具体的治疗方法，并确定有危险的人。特定的生物学异常还将有助于验证精神病诊断并改善疾病的分类。