RELATIONSHIP BETWEEN DNA STRUCTURE AND ADDUCT FORMATION

DNA 结构与加合物形成之间的关系

• 批准号: 7355284
• 负责人: BARRY GOLD
• 金额: $ 0.11万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7355284
• 关键词: RELATIONSHIP; BETWEEN; DNA; STRUCTURE; ADDUCT

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The equilibrium binding and covalent interactions of carcinogens and antineoplastic agents with double-stranded DNA involves complex steric and electronic factors that are not well understood. This study will provide new and fundamental information on (a) the origin of the sequence specificity of antineoplastic DNA crosslinking agents; (b) how to design efficient DNA crosslinking agents; and (c) how the interaction of DNA with charged species, including basic amino acid sidechains, can induce DNA deformation.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。致癌剂和抗肿瘤剂与双链 DNA 的平衡结合和共价相互作用涉及复杂的空间和电子因素，但目前尚不清楚。这项研究将提供以下方面的新的基本信息：(a) 抗肿瘤 DNA 交联剂序列特异性的起源； (b) 如何设计高效的DNA交联剂； (c) DNA 与带电物质（包括碱性氨基酸侧链）的相互作用如何引起 DNA 变形。