Health-related Quality of Life in Teens with Depression

抑郁症青少年的健康相关生活质量

• 批准号: 8146175
• 负责人: FRANCES L LYNCH
• 金额: $ 49.06万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8146175
• 关键词: Health; related; Quality; Life; Teens

DESCRIPTION (provided by applicant): Depression is one of the most common mental disorders among adolescents and has many negative consequences including impaired functioning and risk for future problems, (e.g., poor school performance, impaired relationships, substance abuse, and suicide). Mental health problems in youth often go unrecognized, and, even when they are recognized, most do not receive any treatment. Information on the burden of youth depression could show health system and public health policymakers the importance of teen depression as a health issue--they need accurate information to set priorities and fund programs to encourage youth depression treatment. Public health policymakers are increasingly using measures of health-related quality of life (HRQL) to compare the burden of disease between health conditions and HRQL is especially important in illnesses such as depression, where traditional measures of disease burden, such as mortality and morbidity, do not adequately capture the impact of the illness. Measures that rate the value of different health states, such as utility-based HRQL measures, are particularly helpful in demonstrating the burden of disease, analyzing the cost-effectiveness of new interventions, and setting priorities for clinical and reimbursement policies. No studies that have examined the use of utility-based HRQL measures in youth with depressive disorder. Our ultimate aim is to develop recommendations and guidelines for the assessment of HRQL in youth depression studies and clinical policymaking. This study will extend the understanding of HRQL in teens with depression by completing the following specific aims. First, we will evaluate the cross-sectional validity and reliability of several widely-used generic health status and utility-based HRQL measures in teens. Second, we will examine the sensitivity of the HRQL instruments in detecting clinically meaningful depression symptom change over 12 weeks following depression diagnosis. PUBLIC HEALTH RELEVANCE: Depression in teens is common and disabling. Currently available measures of the burden of depression in teens, such as symptom ratings, do not capture the full impact of depression on teens' lives. Improved measurement of the impact of depression on teen's quality of life would aid in evaluating new treatments and in setting public health policies to address teen depression.

描述（由申请人提供）：抑郁症是青少年中最常见的精神障碍之一，并且具有许多负面后果，包括功能受损和对未来问题的风险（例如，学校表现不佳，关系受损，毒品滥用和自杀）。年轻人的心理健康问题经常被无法识别，即使被认可，大多数人也没有得到任何治疗。有关青年抑郁症负担的信息可以显示卫生系统和公共卫生决策者青少年抑郁症作为健康问题的重要性 - 他们需要准确的信息来设定优先级和资金计划，以鼓励青年抑郁症治疗。公共卫生政策制定者越来越多地使用与健康相关的生活质量（HRQL）的度量来比较健康状况和HRQL之间的疾病负担在诸如抑郁症之类的疾病中尤其重要，例如抑郁症（传统的疾病负担措施，例如死亡率和发病率），没有充分捕捉疾病的影响。评估不同健康状况的价值（例如基于公用事业的HRQL措施）的措施特别有助于证明疾病的负担，分析新干预措施的成本效益，并确定临床和报销政策的优先级。没有研究研究抑郁症青年中基于公用事业的HRQL测量的使用。我们的最终目的是制定针对青年抑郁研究和临床决策评估HRQL评估的建议和准则。这项研究将通过完成以下特定目标来扩展对抑郁症青少年的HRQL的理解。首先，我们将评估几种广泛使用的通用健康状况和青少年基于公用事业的HRQL测量的横截面有效性和可靠性。其次，我们将检查HRQL仪器在抑郁诊断后12周内检测临床上有意义的抑郁症状变化时的敏感性。 公共卫生相关性：青少年抑郁症是普遍且残疾的。目前，青少年抑郁症负担（例如症状评级）的可用措施不会捕获抑郁症对青少年生活的全部影响。改进了对抑郁症对青少年生活质量的影响的测量，将有助于评估新的治疗方法，并制定公共卫生政策以解决青少年抑郁症。